Frequency of rs731236 (Taql), rs2228570 (Fok1) of Vitamin-D Receptor (VDR) gene in Emirati healthy population
Meta Gene Dec 2015 doi:10.1016/j.mgene.2015.09.001
Enas Osmana, Fatme Al Anoutib, Gehad El ghazalic, Afrozul Haqd, Rajaa Mirganie, Habiba Al Safara, f habiba.alsafar@kustar.ac.ae
Vitamin D is getting more attention everyday due to its importance in maintaining bone and calcium homeostasis, cellular proliferation, differentiation and immune response. Vitamin D is derived from diet or elicited in the skin by the activation of 7-dehydrocholesterol, which is an inert molecule that must be activated by ultraviolet light to form pre-vitamin D3. Recent studies connected the gene encoding for vitamin D (VDR) to the genetic control of bone mass and other diseases.
As VDR SNPs have been associated with several disorders and diseases, it's important to investigate the allelic and genotypic distribution among populations. The aim of this study is to determine the frequency of rs731236 (Taq1) and rs2228570 (Fok1) variants in healthy Emirati individuals and compare their genotype and allele distribution with other populations. In this study 282 (female, 187; male, 95) unrelated healthy UAE nationals were involved. Two hundreds and eight two DNA samples been collected to genotype rs731236 (Taq1) and rs2228570 (Fok1) VDR SNPs. Our results indicate that the distribution of the alleles and genotypes of rs731236 (Taq1) and rs2228570 (Fok1) vary considerably in different populations. In the Emirati population the distribution of rs731236 (Taq1) and rs2228570 (Fok1) were AA 38%, AG 42%, GG 20% and AA 27%, AG 42%, GG 31% respectively. The Emirati population genotype and allele distribution of rs731236 (Taq1) and rs2228570 (Fok1) had no difference with Caucasians from USA and France. However, there was significant difference with Asian populations.
 Download the PDF from VitaminDWiki
See also VitaminDWiki
- Vitamin D Receptor category listing has
523 items along with related searches - Vitamin D RECEPTOR pages with DARK SKIN or RACE in title 6 as of Oct 2021
The TOP articles in Vitamin D Receptor are listed here:
- Long-COVID is now the biggest COVID concern - many studies
- Preeclampsia reduced by Vitamin D - many studies
- Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021
- Vitamin D levels in cells, not blood, is important (IVF follicular fluid in this case) – Aug 2021
- Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021
- AI is examining 170,000 potential COVID-19 treatments, Vitamin D is one of only 6 found – Sept 4, 2020
- Does survival of the less fit mean less health (poor genes may be inherited)
- Obesity associated with poor Vitamin D genes (VDR in this study) – Jan 2018
- Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018
- Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019
- Vitamin D receptor (TT), which restricts Vit D to cells, is associated with balance problems in seniors – June 2018
- Cerebral small vessel disease 2.5 X more likely if poor Vitamin D Receptor – Sept 2018
- Obesity in 700 young adults associated with a poor Vitamin D Receptor – Jan 2018
- Health problems that run in families are often associated with low vitamin D
- Many autoimmune diseases associated with latitude and vitamin D receptor – March 2016
- Vitamin D and the skin: Focus on a complex relationship - Nov 2015
- Benefits of Vitamin D often limited by genes
- 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014
- Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014
- Death from melanoma (without ulcers) greatly decreased if have lots of vitamin D receptors – May 2014
- 13 reasons why many seniors need more vitamin D (both dose and level) - July 2023
- Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc.
4812 visitors, last modified 24 Oct, 2021,