Vitamin D measured in 4000 people for many years – longitudinal associations – May 2015

Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements.

Endocrine. 2015 May 30. [Epub ahead of print]
Skaaby T1, Husemoen LL, Thuesen BH, Pisinger C, Hannemann A, Jørgensen T, Linneberg A.
1Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark, tea.skaaby.01@regionh.dk.

VitaminDWiki Summary
BMI -0.3 ng/ml
per 1 kg/m2 increase in BMI
moderately/vigorously physically active
versus sedentary
4.50 ng/ml
(probably outdoors more)
healthy dietary habits
versus unhealthy dietary habits
1.8 ng/ml
1 drink increase in alcohol 0.05 ng/ml (virually nothing)
never smokers versus daily smokers 0.86 ng/ml

See also VitaminDWiki
Overview Obesity and Vitamin D
Overview Sports and vitamin D
Smoking reduces vitamin D - many studies


Several lifestyle factors have been found to be associated with vitamin D status in cross-sectional studies, but it is not clear whether a change in these factors can actually affect the vitamin D level. We investigated the association between repeated measurements of physical activity, body mass index (BMI), diet, alcohol consumption, and smoking habits, and corresponding levels of vitamin D during 5 years of follow-up of a large general population sample. We included 4185 persons who participated and had vitamin D (serum-25-hydroxyvitamin D, 25-OH-D) measurements in the Inter99 study at baseline (1999-2001) and 5-year follow-up. In a subsample, 25-OH-D was also measured at 1- and 3-year follow-ups. We used mixed models to examine the association between repeated measurements of lifestyle factors and 25-OH-D levels. In multivariable analyses of repeated measurements, the difference in 25-OH-D was -0.32 ng/ml (95 % CI -0.37, -0.28) per 1 kg/m2 increase in BMI; 4.50 ng/ml (95 % CI 3.84, 5.15) for persons moderately/vigorously physically active versus sedentary; 1.82 ng/ml (95 % CI 1.09, 2.56) for persons with healthy versus unhealthy dietary habits; 0.05 ng/ml (95 % CI 0.03, 0.07) per 1 standard drink/weak increase in alcohol consumption; and 0.86 ng/ml (95 % CI 0.36, 1.35) for never smokers versus daily smokers. Our study shows that lower BMI, a higher level of physical activity, a healthier diet and possibly a higher alcohol intake, and not smoking, are associated with higher 25-OH-D levels.

PMID: 26024976
Publisher wants $40 for the PDF

References

  1. Hilger, J, Friedel, A, Herr, R, Rausch, T, Roos, F, Wahl, DA (2013)
    A systematic review of vitamin D status in populations worldwide. Br. J. Nutr. 111: pp. 23-45 CrossRef VitaminDWiki
  2. Holick, MF (2007) Vitamin D deficiency. N. Engl. J. Med. 357: pp. 266-281 CrossRef
  3. Skaaby, T, Husemoen, LL, Pisinger, C, Jorgensen, T, Thuesen, BH, Fenger, M (2012) Vitamin D status and cause-specific mortality: a general population study. PLoS ONE 7: pp. e52423 CrossRef
  4. Skaaby, T, Husemoen, LL, Thuesen, BH, Pisinger, C, Jorgensen, T, Roswall, N (2014) Prospective population-based study of the association between serum 25-hydroxyvitamin-D levels and the incidence of specific types of cancer. Cancer Epidemiol. Biomarkers Prev. 23: pp. 1220-1229 CrossRef
  5. Skaaby, T (2015) The relationship of vitamin D status to risk of cardiovascular disease and mortality. Dan. Med. J. 61: pp. 2
  6. Skaaby, T, Husemoen, L, Thuesen, B, Linneberg, A (2015) Prospective population-based study of the association between vitamin D status and incidence of autoimmune disease. Endocrine.
  7. Theodoratou, E, Tzoulaki, I, Zgaga, L, Ioannidis, JP (2014)
    Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ 348: pp. g2035 CrossRef VitaminDWiki
  8. Husemoen, LL, Skaaby, T, Thuesen, BH, Jorgensen, T, Fenger, RV, Linneberg, A (2012) Serum 25(OH)D and incident type 2 diabetes: a cohort study. Eur. J. Clin. Nutr. 66: pp. 1309-1314 CrossRef
  9. Skaaby, T, Husemoen, LL, Pisinger, C, Jorgensen, T, Thuesen, BH, Fenger, M (2012)
    Vitamin D status and changes in cardiovascular risk factors: a prospective study of a general population. Cardiology. 123: pp. 62-70 CrossRef
  10. Skaaby, T, Husemoen, LL, Martinussen, T, Thyssen, JP, Melgaard, M, Thuesen, BH (2013) Vitamin D status, filaggrin genotype, and cardiovascular risk factors: a Mendelian randomization approach. PLoS ONE 8: pp. e57647 CrossRef
  11. Skaaby, T, Husemoen, LL, Pisinger, C, Jorgensen, T, Thuesen, BH, Rasmussen, K (2013) Vitamin D status and 5-year changes in urine albumin creatinine ratio and parathyroid hormone in a general population. Endocrine 44: pp. 473-480 CrossRef
  12. Skaaby, T, Husemoen, LL, Pisinger, C, Jorgensen, T, Thuesen, BH, Fenger, M (2013)
    Vitamin D status and incident cardiovascular disease and all-cause mortality: a general population study. Endocrine 43: pp. 618-625 CrossRef
  13. Skaaby, T, Husemoen, LL, Thuesen, BH, Pisinger, C, Jorgensen, T, Fenger, RV (2014) Vitamin D status and chronic obstructive pulmonary disease: a prospective general population study. PLoS ONE 9: pp. e90654 CrossRef
  14. Yin, L, Ordonez-Mena, JM, Chen, T, Schottker, B, Arndt, V, Brenner, H (2013) Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: a systematic review and meta-analysis. Prev. Med. 57: pp. 753-764 CrossRef
  15. Klingberg, E, Olerod, G, Konar, J, Petzold, M, Hammarsten, O (2015) Seasonal variations in serum 25-hydroxy vitamin D levels in a Swedish cohort. Endocrine.
  16. Brock, K, Huang, WY, Fraser, DR, Ke, L, Tseng, M, Stolzenberg-Solomon, R (2010)
    Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women. J. Steroid Biochem. Mol. Biol. 121: pp. 462-466 CrossRef VitaminDWiki
  17. Greene-Finestone, LS, Berger, C, Groh, M, Hanley, DA, Hidiroglou, N, Sarafin, K (2011)
    25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates. Osteoporos. Int. 22: pp. 1389-1399 CrossRef
  18. Hintzpeter, B, Mensink, GB, Thierfelder, W, Muller, MJ, Scheidt-Nave, C (2008) Vitamin D status and health correlates among German adults. Eur. J. Clin. Nutr. 62: pp. 1079-1089 CrossRef
  19. Hirani, V, Mosdol, A, Mishra, G (2009) Predictors of 25-hydroxyvitamin D status among adults in two British national surveys. Br. J. Nutr. 101: pp. 760-764 CrossRef
  20. Levy, MA, McKinnon, T, Barker, T, Dern, A, Helland, T, Robertson, J (2015)
    Predictors of vitamin D status in subjects that consume a vitamin D supplement. Eur. J. Clin. Nutr. 69: pp. 84-89 CrossRef
  21. Pasco, JA, Henry, MJ, Nicholson, GC, Brennan, SL, Kotowicz, MA (2009) Behavioural and physical characteristics associated with vitamin D status in women. Bone 44: pp. 1085-1091 CrossRef
  22. Thuesen, BH, Skaaby, T, Husemoen, LL, Fenger, M, Jorgensen, T, Linneberg, A (2015)
    The association of serum 25-OH vitamin D with atopy, asthma, and lung function in a prospective study of Danish adults. Clin. Exp. Allergy 45: pp. 265-272 CrossRef
  23. Thuesen, B, Husemoen, L, Fenger, M, Jakobsen, J, Schwarz, P, Toft, U (2012) Determinants of vitamin D status in a general population of Danish adults. Bone 50: pp. 605-610 CrossRef
  24. Jorgensen, T, Borch-Johnsen, K, Thomsen, TF, Ibsen, H, Glumer, C, Pisinger, C (2003) A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99. Eur. J. Cardiovasc. Prev. Rehabil. 10: pp. 377-386 CrossRef
  25. Toft, U, Kristoffersen, L, Ladelund, S, Bysted, A, Jakobsen, J, Lau, C (2008) Relative validity of a food frequency questionnaire used in the Inter99 study. Eur. J. Clin. Nutr. 62: pp. 1038-1046 CrossRef
  26. Ramnemark, A, Norberg, M, Pettersson-Kymmer, U, Eliasson, M (2015) Adequate vitamin D levels in a Swedish population living above latitude 63 degrees N: The 2009 Northern Sweden MONICA study. Int. J. Circumpolar. Health. 74: pp. 27963 CrossRef
  27. A.J. Voipio, K.A. Pahkala, J.S. Viikari, V. Mikkila, C G. Magnussen, N. Hutri-Kahonen et al., Determinants of serum 25(OH)D concentration in young and middle-aged adults. The Cardiovascular Risk in Young Finns Study. Ann Med. 1–10 (2015). doi:10.3109/07853890.2015.1020860
  28. Vimaleswaran, KS, Berry, DJ, Lu, C, Tikkanen, E, Pilz, S, Hiraki, LT (2013) Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 10: pp. e1001383 CrossRef
  29. Supervia, A, Nogues, X, Enjuanes, A, Vila, J, Mellibovsky, L, Serrano, S (2006) Effect of smoking and smoking cessation on bone mass, bone remodeling, vitamin D, PTH and sex hormones. J. Musculoskelet. Neuronal. Interact. 6: pp. 234-241
  30. Cutillas-Marco, E, Fuertes-Prosper, A, Grant, WB, Morales-Suarez-Varela, M (2012)
    Vitamin D deficiency in South Europe: effect of smoking and aging. Photodermatol. Photoimmunol. Photomed. 28: pp. 159-161 CrossRef
  31. Lee, K (2012) Sex-specific relationships between alcohol consumption and vitamin D levels: The Korea National Health and Nutrition Examination Survey 2009. Nutr. Res. Pract. 6: pp. 86-90 CrossRef
  32. Skaaby, T, Husemoen, LL, Borglykke, A, Jorgensen, T, Thuesen, BH, Pisinger, C (2013) Vitamin D status, liver enzymes, and incident liver disease and mortality: a general population study. Endocrine 47: pp. 213-220 CrossRef
  33. Skaaby, T, Husemoen, LL, Linneberg, A (2013) Does liver damage explain the inverse association between vitamin D status and mortality?. Ann. Epidemiol. 23: pp. 812-814 CrossRef
  34. Gascon-Barre, M (1982) Interrelationships between vitamin D3 and 25-hydroxyvitamin D3 during chronic ethanol administration in the rat. Metabolism. 31: pp. 67-72 CrossRef
  35. Turner, RT, Aloia, RC, Segel, LD, Hannon, KS, Bell, NH (1988) Chronic alcohol treatment results in disturbed vitamin D metabolism and skeletal abnormalities in rats. Alcohol. Clin. Exp. Res. 12: pp. 159-162 CrossRef
  36. McClung, JP, Gaffney-Stomberg, E, Lee, JJ (2014)
    Female athletes: a population at risk of vitamin and mineral deficiencies affecting health and performance. J. Trace Elem. Med Biol. 28: pp. 388-392 CrossRef
  37. Ellis, AC, Alvarez, JA, Gower, BA, Hunter, GR (2014) Cardiorespiratory fitness in older adult women: relationships with serum 25-hydroxyvitamin D. Endocrine 47: pp. 839-844 CrossRef
  38. Jenab, M, Salvini, S, Gils, CH, Brustad, M, Shakya-Shrestha, S, Buijsse, B (2009) Dietary intakes of retinol, beta-carotene, vitamin D and vitamin E in the European Prospective Investigation into Cancer and Nutrition cohort. Eur. J. Clin. Nutr. 63: pp. S150-S178 CrossRef
  39. Holick, MF, Binkley, NC, Bischoff-Ferrari, HA, Gordon, CM, Hanley, DA, Heaney, RP (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 96: pp. 1911-1930 CrossRef
  40. Lagunova, Z, Porojnicu, AC, Aksnes, L, Holick, MF, Iani, V, Bruland, OS (2013)
    Effect of vitamin D supplementation and ultraviolet B exposure on serum 25-hydroxyvitamin D concentrations in healthy volunteers: a randomized, crossover clinical trial. Br. J. Dermatol. 169: pp. 434-440 CrossRef
    VitaminDWiki 200 IU needed to increase vitamin D levels by 1 ng (not 100 IU) – summary of 25 studies – Feb 2014

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