Vitamin D and the Innate and Adaptive immune systems – July 2021

Vitamin D in the time of the coronavirus (COVID-19) pandemic - a clinical review from a public health and public mental health perspective

Ther Adv Psychopharmacol 2021 Jul 9; doi: 10.1177/20451253211027699.
Ursula Werneke 1, Fiona Gaughran 2, David M Taylor 3


Study is a wide ranging overview of COVID and Vitamin D,
has a nice chart of the immune system
and a table of Vitamin D levels around the world

Immunity category in VitaminDWiki starts with

263 items in Immunity category

    see also

Virus category listing has 1363 items along with related searches

Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
228 VitaminDWiki pages contained "infection" in title (June 2024)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
   Only the brain is more complex, nothing about Vitamin D

18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection

48 studies are in both Immunity and Virus categories

VitaminDWiki pages containing INNATE OR ADAPTIVE in title (18 as of Jan 2023)

Items found: 18
Title Modified
Complement system (part of innate immunity) needs Vitamin D (50 ng is good) – Sept 2022 01 Oct, 2022
Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022 19 Sep, 2022
Vitamin D improves Sinovac vaccine (fast innate response) - July 2022 24 Aug, 2022
How healthy innate immune systems adapt to viral mutations - Feb 2021 14 Jul, 2022
Strong innate immune systems do not get viral symptoms (COVID-19) – April 2021 14 Jul, 2022
Innate immune suppression by SARS-CoV-2 mRNA vaccinations - April 2022 22 Apr, 2022
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022 29 Jan, 2022
COVID and vaccine spikes damage repair of adaptive immune system DNA (in the lab) - Oct 2021 06 Jan, 2022
Vitamin D and the Innate and Adaptive immune systems – July 2021 22 Jul, 2021
19X fewer COVID-19 infections if innate immune system activated – trial Oct 21, 2020 21 Nov, 2020
Vitamin D fortification of the innate immune system can be limited by 15 genes – April 2020 19 Apr, 2020
Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019 12 Jul, 2019
Genes evolve to adapt to excess or low vitamin D (Eskimo, Reindeer, etc.) – June 2019 21 Jun, 2019
Cardiovascular Diseases associated with both Vitamin D and innate immune system (TLR) – Oct 2017 28 Oct, 2017
Off topic: Ecoli adapts to 1000 times toxic dose of antibiotics in just 11 days – Sept 2016 20 Sep, 2016
Innate and adaptive immune systems probably helped by vitamin D – Oct 2014 14 Aug, 2016
Dengue virus avoids the INNATE immune system – Dec 2012 02 May, 2016
Adaptive immunity (cancer, viruses, autoimmune) and vitamin D – April 2016 25 Apr, 2016

 Download the PDF from VitaminDWiki

Individuals with serious mental disorders (SMD) may have a higher risk of vitamin D (VIT-D) deficiency. They also experience higher mortality because of coronavirus disease 2019 (COVID-19) infection. Therefore, we have conducted a comprehensive review to examine the significance of VIT-D for public health and public mental health during the ongoing COVID-19 pandemic. This review had three specific aims, from a global perspective to (a) create a profile of VIT-D and review the epidemiology of VIT-D deficiency, (b) explore VIT-D deficiency as risk factor for SMD and COVID-19 infections and (c) examine the effectiveness of VIT-D supplementation for both conditions. We found that, in terms of SMD, the evidence from laboratory and observational studies points towards some association between VIT-D deficiency and depression or schizophrenia. Mendelian randomisation studies, however, suggest no, or reverse, causality. The evidence from intervention studies is conflicting. Concerning COVID-19 infection, on proof of principle, VIT-D could provide a plausible defence against the infection itself and against an adverse clinical course. But data from observational studies and the first preliminary intervention studies remain conflicting, with stronger evidence that VIT-D may mitigate the clinical course of COVID-19 infection rather than the risk of infection in the first place. From a public health and public mental health point of view, based on the currently limited knowledge, for individuals with SMD, the benefits of VIT-D optimisation through supplementation seem to outweigh the risks. VIT-D supplementation, however, should not substitute for vaccination or medical care for COVID-19 infection.

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