Vitamin D and Neurological Diseases: An Endocrine View
Int. J. Mol. Sci. 2017, 18, 2482; doi:10.3390/ijms18112482
Carolina Di Somma , Elisabetta Scarano , Luigi Barrea , Volha V. Zhukouskaya 2,
Silvia Savastano 2, Chiara Mele<1,5, Massimo Scacchi4,6 , Gianluca Aimaretti ,
Annamaria Colao 2 and Paolo Marzullo paolo.marzullo@med.uniupo.it
Types of evidence that Vitamin D helps brain problems - 2014
- Multiple Sclerosis, Alzheimer’s and Parkinson’s need more than 30 ng of Vitamin D – review Nov 2017
- ALS fought by vitamin D - many studies
- Overview Parkinson's and Vitamin D
- Overview MS and vitamin D
- Alzheimer’s, Parkenson’s, and Multiple Sclerosis – vitamin D may prevent and treat – Oct 2017
Overview Alzheimer's-Cognition and Vitamin D has the following summary
- FACT: Cognitive decline is 19X more likely if low vitamin D
- FACT: Dementia is associated with low vitamin D levels.
- FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
- FACT: Dementia is associated with low vitamin D - many studies
- FACT: Alzheimer's Disease is 4X less likely if high vitamin D
- FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
- FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
- OBSERVATION: Reports of increased vitamin D levels result in improved cognition
- OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
- OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
- OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
- OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
- OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
- OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
- OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
- OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
- OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
- OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
- OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
- OBSERVATION: End of Alzheimer's videos, transcripts and many studies protocol has been very successful
- It adjusts Vitamin D, B-12, Iron, Omega-3, food, etc, and can now be done at home.
- FACT: Vitamin D is extremely low cost and has very very few side effects
- CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
- PREDICTION MET: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
There are 13+ Alzheimer’s meta-analyses in VitaminDWiki
There are 97+ Alzheimer’s studies in VitaminDWiki
Dementia is associated with low vitamin D - many studies 50+ studies
16+ studies in both categories Cognitive and Omega-3
Dementia
- Dementia risk factor is increased by 1.5 if low vitamin D – meta-analysis Jan 2017
- Dementia less likely with increased levels of Magnesium etc.
- Dementia 19X more likely if low vitamin D – Jan 2012
- Dementia 13X more likely in elderly with low vitamin D – May 2014
- Dementia risk significantly increased if have 4 chronic diseases – all associated with low vitamin D – Sept 2015
- Search VitaminDWiki for dementia anywhere in text 960 items Nov 2017
Endocrine and Genes
- Autocrine, Paracrine and Endocrine - simple chart
- Brain cells can probably activate Vitamin D without liver or kidney (at least in rats) – Sept 2017
Vitamin D blood test misses a lot
Download the PDF from VitaminDWiki
Abstract: Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular mediators and elicit many physiological functions. In vitro and in vivo studies have, in fact, increasingly focused on the "non-calcemic" actions of vitamin D, which are associated with the maintenance of glucose homeostasis, cardiovascular morbidity, autoimmunity, inflammation, and cancer. In parallel, growing evidence has recognized that a multimodal association links vitamin D system to brain development, functions and diseases. With vitamin D deficiency reaching epidemic proportions worldwide, there is now concern that optimal levels of vitamin D in the bloodstream are also necessary to preserve the neurological development and protect the adult brain. The aim of this review is to highlight the relationship between vitamin D and neurological diseases.