J Clin Oncol. 2010 Aug 16.
Drake MT, Maurer MJ, Link BK, Habermann TM, Ansell SM, Micallef IN, Kelly JL, Macon WR, Nowakowski GS, Inwards DJ, Johnston PB, Singh RJ, Allmer C, Slager SL, Weiner GJ, Witzig TE, Cerhan JR.
College of Medicine, Mayo Clinic, Rochester, MN; the College of Medicine, University of Iowa, IA City, IA; and the University of Rochester, Rochester, NY.
PURPOSE Vitamin D insufficiency is common in the United States, with low levels linked in some studies to higher cancer incidence, including non-Hodgkin's lymphoma (NHL). Recent data also suggest that vitamin D insufficiency is related to inferior prognosis in some cancers, although there are no data for NHL.
PATIENTS AND METHODS We tested the hypothesis that circulating 25-hydroxyvitamin D [25(OH)D] levels are predictive of event-free survival (EFS) and overall survival (OS) in a prospective cohort of 983 newly diagnosed patients with NHL. 25(OH)D and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] levels were measured by liquid chromatography-tandem mass spectrometry.
Results Mean age at diagnosis was 62 years (range, 19 to 94 years); 44% of patients had insufficient 25(OH)D levels (< 25 ng/mL) within 120 days of diagnosis. Median follow-up was 34.8 months; 404 events and 193 deaths (168 from lymphoma) occurred.
After adjusting for known prognostic factors and treatment, 25(OH)D insufficient patients with diffuse large B-cell lymphoma (DLBCL) had
inferior EFS (hazard ratio [HR], 1.41; 95% CI, 0.98 to 2.04) and OS (HR, 1.99; 95% CI, 1.27 to 3.13); 25(OH)D
insufficient patients with T-cell lymphoma also had inferior EFS (HR, 1.94; 95% CI, 1.04 to 3.61) and OS (HR, 2.38; 95% CI, 1.04 to 5.41).
There were no associations with EFS for the other NHL subtypes. Among patients with DLBCL and T-cell lymphoma, higher 1,25(OH)(2)D levels were associated with better EFS and OS, suggesting that any putative tumor 1-alpha-hydroxylase activity did not explain the 25(OH)D associations.
CONCLUSION 25(OH)D insufficiency was associated with inferior EFS and OS in DLBCL and T-cell lymphoma. Whether normalizing vitamin D levels in these patients improves outcomes will require testing in future trials. PMID: 20713849
about 2X better survival if > 25 ng of vitamin D
Typical survival added by VitaminDWiki: 60% (shown in Red)
The second chart implies that some things may get better with higher levels of vitamin D
- Non-Hodgkin Lymphoma 20 percent more likely if low UV – meta-analysis April 2019
- Lymphoid malignancies greatly reduced if slightly more UVB where you live – May 2011
- Overview Cancer and vitamin D
- Chemotherapy might be amplified by vitamin D
- Cancer - After Diagnosis category listing has
84 items along with related searches
- Vitamin D appears to both prevent and treat various cancers – Mar 2011
- Is vitamin D the only supplement which consistently helps cancer survivors – Aug 2010
- Cancer survivors helped with lots of Vitamin D – Aug 2010
- Metastatic Cancer is maybe reduced by vitamin D - 5 articles
- Vitamin D reduces lung damage due to radiotherapy – Oct 2011
- Vitamin D and breast cancer radiation
Short URL for this page = http://is.gd/lymphoma