The serum vitamin D levels in children with urinary tract infection: a case-control study
New Microbes New Infect . 2021 Jul 5;43:100911. doi: 10.1016/j.nmni.2021.100911
M Sadeghzadeh 1, P Khoshnevisasl 2, N Motamed 3, L Faghfouri 4
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Urinary tract infection (UTI) is one of the most common infections in infants and children. The aim of this study is to evaluate the association between vitamin D levels and urinary tract infections in children. This case-control study was performed on 80 children aged 1-12 years with urinary tract infection referred to the pediatric clinic of Mousavi Hospital in Zanjan, Iran. For each patient in the case group, an individual of the same age and sex was selected in the control group. Vitamin D was measured by the ELISA method. Statistical analysis was performed by SPSS V22 software. In this study, 80 children were divided into two groups of 40 cases (UTI) and control. Serum levels of vitamin D in the case group were significantly lower than in the control group [OR (95%CI) = 3.316 (1.286-8.550),( p = 0.013)].
In females, serum levels of vitamin D in cases were significantly lower than for controls [OR (95%CI) = (5.417 (1.685-17.417), P-value = 0.005)]. No significant relationship was found between serum levels of vitamin D in cases and controls regarding male gender, age and weight.
Conclusions: This study showed that vitamin D deficiency has a significant relationship with the prevalence of UTI in children. Vitamin D deficiency and female gender are more frequent risk factors for UTI.