Intake of 25-Hydroxyvitamin D 3 May Reduce the Severity of Upper Respiratory Tract Infection: Post hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study
Nutrients, 2020 Dec 8;12(12):E3769. doi: 10.3390/nu12123769.
Yoshiki Shimizu 1, Yukihiko Ito 1, Nobuo Uotsu 1, Kei Yui 1
It is rare to find that as little as 400 IU of Vitamin D produces a benefit in adults
- Just 400 IU of daily Vitamin D reduced miscarriage (recurrent) by 3.5 times – RCT July 2016
- During pregnancy even 400 IU helps metabolic status – RCT July 2013
- Heart failure markers reduced by 400 IU of vitamin D and Calcium (surprise) – RCT Jan 2015
- 400 iu of vitamin D is like 24 seconds of sun in a swimsuit in Los Angeles
Breathing category starts with the following
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Not clear what the numbers represent
Mental Not clear what the numbers represent
Fewer UTRI events - but not statistically significant
To evaluate the effects of 25-hydroxyvitamin D3 (25OHD) on symptoms at the onset of the upper respiratory tract infection (URTI) in subjects with insufficient or deficient serum 25-hydroxyvitamin D levels, we conducted a post hoc analysis of data from a randomized, placebo-controlled study; the subjects received 10 μg of 25OHD per day or a placebo for 16 weeks. The Wisconsin Upper Respiratory Symptom Survey-21 was used to determine URTI. The study endpoints included WURSS-21 scores, number of URTI events, and proportion of medication (antibiotics, antipyretic analgesics) usage. We found that the physical symptom scores for "Runny nose," "Sneezing," and "Head congestion" were significantly lower in the 25OHD group than in the placebo group; for all items except "Breathe easily, "the quality of life" scores were significantly improved in the 25OHD group. There was no significant difference in the number of URTI events or the proportion of medication use between the groups. Collectively, the findings of this study indicate that a sufficient 25OHD intake can reduce physical symptoms at the onset of upper respiratory tract infection, particularly nasal symptoms, and may improve the quality of life at the time of onset.