Free and Bioavailable 25-Hydroxyvitamin D Concentrations are Associated With Disease Activity in Pediatric Patients With Newly Diagnosed Treatment Naïve Ulcerative Colitis.
Inflamm Bowel Dis. 2018 Feb 15;24(3):641-650. doi: 10.1093/ibd/izx052.
Sauer CG1, Loop MS2, Venkateswaran S1, Tangpricha V1, Ziegler TR1, Dhawan A3, McCall C4, Bonkowski E4, Mack DR5, Boyle B6, Griffiths AM7, Leleiko NS8, Keljo DJ9, Markowitz J10, Baker SS11, Rosh J12, Baldassano RN13, Davis S2, Patel S1, Wang J2, Marquis A2, Spada KL14, Kugathasan S1, Walters T7, Hyams JS14, Denson LA4.
Vitamin D Binding Protein restricts the bio-availability of Vitamin D
Vitamin D Binding Protein category listing hasSearch VitaminDWiki for GC OR VDBP 3,800 items as of May 2019
Did not search for "Vitamin D Binding Protein" as that phrase is on virtually every page in VitaminDWiki
- Epilepsy 1.4 X more likely if poor Vitamin D Binding Protein (Han Chinese) – July 2018
- Kidney failure 1.7X more likely - Vitamin D Binding Protein – Feb 2016
- Major depression associated with vitamin D Binding Protein in youths – March 2018
- Hypothesis – Bipolar disorder diagnose based on results of vitamin D-binding protein test – March 2018
- BMD associated with free and bioavailable vitamin D – March 2011
- Bone density correlates better with free D (calculated) rather than measured vitamin D – Jan 2014
- Bioavailable Vitamin D is the same blacks and whites, but measured vit D is not – Oct 2014
- Total Vitamin D (standard measure) = 1+2+3
- 1) bio-available D
- 2) tied up with albumin D
- 3) D tied up with D binding protein
The articles in both categories of Darker Skin and Vitamin D Binding Protein are here:
- T1 Diabetes 6.5 X more likely in South African Blacks if poor Vitamin D Binding Protein – July 2022
- Sweat types, folate, binding protein, lighter skin in females and Vitamin D – Jan 2020
- 10 reasons for poor response to Vitamin D (race, binding protein, etc.) – Nov 2017
- Prostate Cancer risk in black men increased 2X having poor Vitamin D Binding Protein – July 2017
- 5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015
- Bioavailable Vitamin D is the same blacks and whites, but measured vit D is not – Oct 2014
- Blacks have lower vitamin D levels, but OK active vitamin D levels (VDBP) - Feb 2015
- Vitamin D-binding protein and vitamin D status of black Americans and white Americans – Nov 2013
Items in both categories of Pregnancy and Vitamin D Binding Protein are listed here:
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preeclampsia 11X more likely if poor Vitamin D Binding Protein (South Africa) - Sept 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Fetal Growth poor if Vitamin D-Binding Protein gene poor – Feb 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Preeclampsia changes to Vitamin D Binding Protein reduces Vitamin D in placenta – Dec 2016
- Bio-available Vitamin D is reduced by half during pregnancy – Jan 2017
- Changes during pregnancy of vitamin D (decrease), DBP (2X) and albumin (0.8X) – Oct 2014
Gut category listing contains the following
- "Ulcerative Colitis" OR UC 839 items Jan 2020
- "celiac disease" OR CD 1830 items July 2019
- IBS or IBD or IRRITABLE BOWEL in title of 41 VitaminDWiki pages as of Aug 2022
- Gut-Friendly forms of vitamin D
- such as: bio-emulsion, topical, spray, sublingual, inhaled, injection .
Genetics chart shows the total vitamin D test is upstream for the Binding Protein
Vitamin D blood test is invisible Binding Protein
Download the PDF from VitaminDWiki
Higher levels of Free and Bio-available associated with less Colitis
Both Free and Bioavailable plateau about 40 ng total
Thus a total >40ng should be associated with less Colitis
BACKGROUND:
Vitamin D regulates intestinal epithelial and immune functions, and vitamin D receptor deficiency increases the severity of murine colitis. Bioavailable 25-hydroxyvitamin D (25(OH)D) is available to target tissues and may be a driver of immune function. The aim is to evaluate the relationship of bioavailable 25(OH)D to the clinical expression of treatment naive pediatric ulcerative colitis (UC).
METHODS:
The PROTECT (Predicting Response to Standardized Pediatric Colitis Therapy) study enrolled children ≤17 years newly diagnosed with UC. Free and total 25(OH)D were directly measured and 25(OH)D fractions were compared with disease activity measures.
RESULTS:
Data were available on 388 subjects, mean age 12.7 years, 49% female, 84% with extensive/pancolitis. The median (IQR) total 25(OH)D concentration was 28.5 (23.9, 34.8) ng/mL, and 57% of subjects demonstrated insufficient vitamin D status (25(OH)D < 30 ng/mL). We found no evidence of association between total 25(OH)D and disease activity. Regression models adjusted for age, sex, race, and ethnicity demonstrated that an increase from 25th to 75th percentile for bioavailable and free 25(OH)D were associated with a mean (95th CI) decrease in the Pediatric Ulcerative Colitis Activity Index (PUCAI) of -8.7 (-13.7, -3.6) and -3.1 (-5.0, -1.2), respectively. No associations were detected between 25(OH)D fractions and fecal calprotectin or Mayo endoscopy score.
CONCLUSIONS:
Vitamin D insufficiency is highly prevalent in children with newly diagnosed UC. We found associations of free and bioavailable, but not total 25(OH)D, with PUCAI. Bioavailable vitamin D may contribute to UC pathophysiology and clinical activity.
| 2931 visitors, last modified 10 May, 2019, |