UV helped EAE mice (MS) designed to not respond to Vitamin D – Oct 2019

UV light suppression of EAE (a mouse model of multiple sclerosis) is independent of vitamin D and its receptor.

Proc Natl Acad Sci U S A. 2019 Oct 21. pii: 201913294. doi: 10.1073/pnas.1913294116.
Irving AA1, Marling SJ1, Seeman J2, Plum LA1, DeLuca HF3.
1 Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
2 Product Development, Organic Lab, DiaSorin Inc., Stillwater, MN 55082.
3 Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706; deluca@biochem.wisc.edu.

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Vitamin D and sunlight have each been reported to protect against the development of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). To date, the contribution of each has been unclear as ultra violet (UV) exposure also causes the generation of vitamin D in the skin. To examine whether the UV based suppression of EAE results, at least, in part from the production of vitamin D, we studied the effect of UV light on EAE in mice unable to produce 7-dehydroxycholesterol (7-DHC), the required precursor of vitamin D. Furthermore, we examined UV suppression of EAE in mice devoid of the vitamin D receptor (VDR). Our results demonstrate that UV light suppression of EAE occurs in the absence of vitamin D production and in the absence of VDR. Future investigations will focus on identifying the pathway responsible for the protective action of UV in EAE and presumably human MS.

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