- Vitamin D supplementation to prevent tuberculosis infection in South African schoolchildren: multicentre phase 3 double-blind randomised placebo-controlled trial (ViDiKids)
14 studies of TB and Vitamin D Intervention - VitaminDwiki – Tuberculosis category contains
- VitaminDwiki – Overview Tuberculosis and Vitamin D contains
Vitamin D supplementation to prevent tuberculosis infection in South African schoolchildren: multicentre phase 3 double-blind randomised placebo-controlled trial (ViDiKids)
Int J Infect Dis. 2023 May 19;S1201-9712(23)00562-3. doi: 10.1016/j.ijid.2023.05.010
Keren Middelkoop 1, Justine Stewart 1, Neil Walker 2, Carmen Delport 3, David A Jolliffe 4, Anna K Coussens 5, James Nuttall 6, Jonathan C Y Tang 7, William D Fraser 7, Christopher J Griffiths 2, Geeta Trilok Kumar 8, Suzanne Filteau 9, Richard L Hooper 2, Robert J Wilkinson 10, Linda-Gail Bekker 3, Adrian R Martineau 11Background: Vitamin D metabolites induce innate antimycobacterial responses in vitro. Observational studies consistently report independent associations between vitamin D deficiency and increased susceptibility to Mycobacterium tuberculosis infection.
Methods: We conducted a randomised placebo-controlled trial to determine whether weekly oral supplementation with 10,000 IU vitamin D3 for 3 years reduced risk of sensitisation to M. tuberculosis in Cape Town schoolchildren aged 6-11 years with negative QuantiFERON-TB Gold Plus (QFT-Plus) assay results at baseline. The primary outcome was a positive end-trial QFT-Plus result, analysed using a mixed effects logistic regression model with school of attendance included as a random effect.
Results: 1682 children attending 23 schools were randomised (829 to vitamin D, 853 to placebo). Mean end-study 25(OH)D concentrations in participants randomised to vitamin D vs. placebo were 104.3 vs. 64.7 nmol/L, respectively (95% CI for difference, 37.6 to 41.9 nmol/L). 76/667 (11.4%) participants allocated to vitamin D vs. 89/687 (13.0%) participants allocated to placebo tested QFT-Plus positive at 3-year follow-up (adjusted odds ratio 0.86, 95% CI 0.62 to 1.19, P=0.35).
Conclusions: Weekly oral supplementation with 10,000 IU vitamin D3 for 3 years elevated serum 25(OH)D concentrations among Cape Town schoolchildren but did not reduce their risk of QFT-Plus conversion.
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14 studies of TB and Vitamin D Intervention This list is automatically updated
- TB treatment helped by the addition of Vitamin D (100,000 IU bi-weekly) – RCT April 2024
- Tuberculosis not prevented by a tiny amount of vitamin D (equiv to 1,400 IU daily) – RCT May 2023
- Tuberculosis treatment helped a bit by a bit of Vitamin D - RCT Feb 2022
- TB not prevented by a small amount of Vitamin D (2,000 IU daily average, Mongolia) – RCT July 2020
- TB not treated by vitamin D given for only 2 months – RCT Sept 2017
- Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT Jan 2017
- Tuberculosis treatment greatly helped by injection of 200,000 IU of vitamin D – RCT April 2016
- Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
- Tuberculosis not treated by lots of vitamin D for 16 weeks – RCT Sept 2015
- Every TB patient benefited from 2 doses of 600,000 IU of vitamin D – RCT Jan 2013
- TB treatment helped with Vitamin D – RCT Sept 2012
- Probability of getting TB reduced 60 percent with just 800 IU of vitamin D – RCT Aug 2012
- Overview Tuberculosis and Vitamin D
- Evaluating the vitamin D evidence - Heaney Dec 2010
VitaminDwiki – Tuberculosis category contains
121 Tuberculosis studies: 14 RCT, 14 Meta-analyses, 8 Vitamin D Receptor - TB patients had low Vitamin D and poor Vitamin D receptor – June 2019
- Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT Jan 2017
- Receptor-related diseases respond especially well to high-dose Vitamin D
- Pulmonary Tuberculosis 2X more likely if poor Vitamin D Receptor (Mexico) – April 2018
- TB not prevented by a small amount of Vitamin D (2,000 IU daily average, Mongolia) – RCT July 2020
- Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
- Latent Tuberculosis 44 percent less likely if Vitamin D more than 30 ng - 14th meta-analysis Jan 2022
- Tuberculosis (multi-drug resistant) was 13.4 X more likely to be quickly cleared with Vitamin D - Meta-analysis Feb 2019
- No tuberculosis if more than 80 ng of vitamin D (cattle) - Jan 2022
see also Overview Tuberculosis and Vitamin D Breathing category
TB has been increasing
VitaminDwiki – Overview Tuberculosis and Vitamin D contains
Many studies have found that Vitamin D both PREVENTS and TREATS TB
- As with many other diseases, we expect that there will be at least a 4X range of vitamin D due to:
- 4X range in the response in the vitamin D blood level for the same IU dose - for healthy, non-obese, people
- Poor Vitamin D Receptor activation results in far less vitamin D getting to cells
- However, a VDR restriction is not noticed by Vitamin D blood tests
- UV appears to be as powerful or perhaps more powerful than vitamin D in TREATING TB
- Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
- TB 10X less likely to catch if have sufficient vitamin D – Dec 2011
- Trials using small vitamin D doses neither prevent nor treat TB 2023 2022 2020
- No tuberculosis if more than 80 ng of vitamin D (cattle) - Jan 2022
- Humans need a lot of Vitamin D as well
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