Oral Vitamin D Therapy in Patients with Psoriasis
Nutrients. 2021 Jan 6;13(1):E163. doi: 10.3390/nu13010163.
Ana Maria Alexandra Stanescu 1, Anca Angela Simionescu 2, Camelia Cristina Diaconu 3
- 1 Department of Family Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
- 2 Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
- 3 Department of Internal Medicine, Clinical Emergency Hospital of Bucharest, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
- Psoriasis reduced for those getting Vitamin D levels above 50 ng – RCT Feb 2018
- Psoriasis severity associated with low vitamin D (10 studies) – meta-analysis Jan 2018
- UV has treated psoriasis for over a century, guidelines finally agreed upon – Aug 2019
- A tiny amount of Calcitiol (activated Vitamin D) for only 4 weeks does not help (sleep apnea in this case) – May 2021
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Vitamin D treatment is effective when applied topically to the skin for plaque-type psoriasis. Oral vitamin D supplementation might be effective as an adjuvant treatment option in psoriasis. This umbrella review aimed to highlight the current knowledge regarding the use of oral vitamin D for treatment of patients with psoriasis. We performed a literature search and identified 107 eligible full-text articles that were relevant to the research interest. Among these, 10 review articles were selected, and data were extracted.
A data synthesis showed that only a few studies monitored oral vitamin D efficacy in patients with psoriasis. No studies investigated the optimal dose of systemic vitamin D in psoriasis.
However, most studies did not observe side effects for doses within a relatively narrow range 0.25 to 2 μg/day). These results suggest that more large-scale studies are needed to determine the efficacy, optimal dose, and adverse effects of vitamin D administration in patients with psoriasis.