Thyroid Cancer 1.4 X higher risk if low vitamin D– meta-analysis Feb 2018

Association between vitamin D deficiency and risk of thyroid cancer: a case-control study and a meta-analysis.

J Endocrinol Invest. 2018 Feb 20. doi:10.1007/s40618-018-0853-9
Hu MJ1, Zhang Q1, Liang L1, Wang SY2, Zheng XC2, Zhou MM1, Yang YW1, Zhong Q1, Huang F3.

PURPOSE: Although vitamin D is reportedly associated with various cancers, the association between vitamin D and thyroid cancer is indefinite. We aimed to investigate whether this association applies to thyroid cancer (TC).

A total of 276 Chinese Han people were recruited in a current matched case-control study. Multivariable conditional logistic regression was computed to estimate the association between plasma 25(OH)D and papillary thyroid cancer (PTC). In addition, we searched relevant studies in PubMed and Web of Science databases before December 2017 to conduct a meta-analysis.

In our case-control study, plasma 25(OH)D concentration was inversely associated with PTC risk (highest tertile vs lowest tertile: adjusted OR = 0.25; 95% CI 0.10, 0.61; Ptrend = 0.003). This association was independent of body mass index and physical activity (all adjusted Pinteraction > 0.05).
A total of 11 studies were included in the meta-analysis, among which ten studies have been published and one was our case-control study. Compared with 25(OH)D non-deficient group, the pooled OR of TC was 1.42 (95% CI 1.17, 1.73) in the deficient group. Similarly, blood 25(OH)D levels in patients with TC were tend to be lower than those in the controls (SMD = - 0.20, 95% CI - 0.36, - 0.03).

CONCLUSIONS: A high level of circulating 25(OH)D was associated with a decreased TC risk. This association has important significance in public health and should, therefore, be further studied.

Int. J. Mol. Sci. 2022, 23(21), 13661;
by Adam Maciejewski and Katarzyna Lacka
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, 60355 Poznan, Poland

Vitamin D, formerly known for its role in calcium-phosphorus homeostasis, was shown to exert a broad influence on immunity and on differentiation and proliferation processes in the last few years. In the field of endocrinology, there is proof of the potential role of vitamin D and vitamin D-related genes in the pathogenesis of thyroid cancer—the most prevalent endocrine malignancy. Therefore, the study aimed to systematically review the publications on the association between vitamin D-related gene variants (polymorphisms, mutations, etc.) and thyroid cancer. PubMed, EMBASE, Scopus, and Web of Science electronic databases were searched for relevant studies. A total of ten studies were found that met the inclusion criteria.
Six vitamin D-related genes were analyzed (

  • VDR—vitamin D receptor,
  • CYP2R1—cytochrome P450 family 2 subfamily R member 1,
  • CYP24A1—cytochrome P450 family 24 subfamily A member 1,
  • CYP27B1—cytochrome P450 family 27 subfamily B member 1,
  • DHCR7—7-dehydrocholesterol reductase and
  • CUBN—cubilin).

Moreover, a meta-analysis was conducted to summarize the data from the studies on VDR polymorphisms (rs2228570/FokI, rs1544410/BsmI, rs7975232/ApaI and rs731236/TaqI). Some associations between thyroid cancer risk (VDR, CYP24A1, DHCR7) or the clinical course of the disease (VDR) and vitamin D-related gene polymorphisms were described in the literature. However, these results seem inconclusive and need validation. A meta-analysis of the five studies of common VDR polymorphisms did not confirm their association with increased susceptibility to differentiated thyroid cancer. Further efforts are necessary to improve our understanding of thyroid cancer pathogenesis and implement targeted therapies for refractory cases
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VitaminDWiki: Cancer- Other category with THYROID in title (7 as of Oct 2022)

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VitaminDWiki - Cancer category (includes a VDR section)

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

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