STRATIFYING CARDIOVASCULAR RISK BY VITAMIN D LEVELS: WHAT ARE THE OPTIMAL CUTOFFS?
31,000 Seniors - average age 67
The following is clipped from the attached 3 page poster of March 2010
Outcomes for those having blood level of vitamin D< 10ng/ml vs those having > 43 ng/ml
If outcome shows HR = 2, then a person having >43 ng/ml is 2X less likely to have the outcome than if he had <10 ng/ml
HR defined below the table
hazard ratio = A measure of how often a particular event happens in one group compared to how often it happens in another group, over time. In cancer research, hazard ratios are often used in clinical trials to measure survival at any point in time in a group of patients who have been given a specific treatment compared to a control group given another treatment or a placebo. A hazard ratio of one means that there is no difference in survival between the two groups. A hazard ratio of greater than one or less than one means that survival was better in one of the groups.
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The following is the text - for translation to other languages
Outcomes
<10 vs. >43
10-19 vs. >43
20-43 vs. >43
Death
HR=1.80, p<0.0001
HR=1.24, p=0.03
HR=0.80, p=0.02
Diabetes
HR=1.54, p<0.0001
HR=1.39, p<0.0001
HR=1.16, p=0.01
CAD
HR=1.40, p=0.001
HR=1.26, p=0.001
HR=1.04, p=0.55
MI
HR=2.70, p=0.002
HR=1.68, p=0.04
HR=0.95, p=0.83
HF
HR=1.52, p<0.0001
HR=1.17, p=0.07
HR=0.96, p=0.65
Depression
HR=1.26, p=0.05
HR=1.32, p=0.001
HR=1.10, p=0.24
Renal Failure
HR=1.72, p<0.0001
HR=1.26, p=0.001
HR=1.07, p=0.27
Hypertension (n=13,507)
HR=2.15, p<0.0001
HR=1.47, p<0.0001
HR=1.23, p=0.04
Diabetes (n=23,592)
HR=2.45, p<0.0001
HR=1.78, p<0.0001
HR=1.12, p=0.41
MI (n=30,067)
HR=2.55, p=0.007
HR=1.62, p=0.08
HR=0.81, p=0.43
HF(n=27,368)
HR=2.09, p<0.0001
HR=1.58, p=0.002
HR=1.16, p=0.28
Depression (n=25,737)
HR=1.97, p<0.0001
HR=1.51, p=0.001
HR=1.17, p=0.19
Renal Failure (n=26,805)
HR=2.11, p<0.0001
HR=1.19, p=0.15
HR=0.95 p=0.62