T-cells need at least 40-50 ng of Vitamin D to fight COVID-19 - June 2021
By: Paul E. Alexander, PhD, Health Research Methodologist Evidence-Based-Medicine
Department of Health Research Methods, Evidence and Impact
McMaster University Assistant Professor http://hei.mcmaster.ca/
GUIDE Research Methods Group http://guidecanada.org/
T-lymphocytes require a level of minimum 40ng/mL (optimally 50) in order to function properly (internal cell signaling). For example, India has a severe insufficiency of vitamin D (97% for adults and elderly had 91% outright deficiency (<20ng/ml).
Evidence indicates that persons with auto-immunity often have a CD8+ T-cell deficiency. CD8+T-cells express the highest amount of the Vitamin D receptors of all immune system cells and can be upregulated with high-dose Vitamin D. A rapid and competent response by CD8+T-cells is a game-changer in COVID-19 outcomes. “Antibody response is often a poor marker of prior coronavirus infection, particularly in mild infections, and is shorter-lived than virus-reactive T-cells”
Researchers argue that monitoring and assessing circulating vitamin D levels status and clinical prognostic indices in COVID-19 patients is critical in the responding. “Vitamin D deficiency is associated with compromised inflammatory responses and higher pulmonary involvement in COVID-19 affected patients. Vitamin D assessment, during COVID-19 infection, could be a useful analysis for possible therapeutic interventions”.
Researchers report that in order for T cells to become active members of the body's immune system, “they must transition from so-called "naive" T cells into either killer cells or helper cells (which are charged with "remembering" specific invaders). And, if ample vitamin D is not around, the T cells do not make that crucial transition”. "When a T cell is exposed to a foreign pathogen, it extends a signaling device of 'antenna' known as a vitamin D receptor, with which it searches for vitamin D," Geisler said in a prepared statement. If there is an inadequate vitamin D level, he noted, "they won't even begin to mobilize."
Persons with auto-immunity need higher doses of Vitamin D to modulate the immune system. “A 2009 Archives of Internal Medicine study found that 77 percent of U.S. adults and teenagers surveyed did not have the estimated minimum healthful level of 30 nanograms per milliliter in their blood. And just three percent of blacks in the survey were getting enough of the vitamin”.
VitaminDWiki
- Covid-19, T cells, and Vitamin D
- Autoimmune diseases and over-active T cells (which are deactivated by vitamin D) – March 2014
VitaminDWiki - Immunity category starts with
see also
Virus category listing hasOverview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
228 VitaminDWiki pages contained "infection" in title (June 2024)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
Only the brain is more complex, nothing about Vitamin D
18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection
VitaminDWiki - Immunity and Virus:
- Need better COVID drugs for immunocompromized (ignores Vitamin D) - Sept 2024
- Many viral diseases can be fought by immune system-augmented Vitamin D - Sunil Aug 2024
- Pfizer COVID vaccinations resulted in altering immune systems (increased IgG4 ) – Aug 2024
- Viral infections reduced 40% by monthly 100,000 IU Vitamin D – RCT review Aug 2024
- Global surge in infectious diseases as over 40 countries report outbreaks 10-fold over pre-pandemic levels - June 2024
- Vitamin D: Viral infections, Infectious diseases, EBV and MS, Virus and Cancers – Grant March 2024
- Immune System tolerance is inversely related to the number of COVID vaccinations (PubMed analysis) - Oct 2023
- Fight infections such as COVID with 50 ng of Vitamin D – Sunil Dec 2022
- The vitamins and minerals that help the immune system respond to respiratory viruses – Dec 2022
- A year after 2nd COVID vaccination, stems cells not available to fetus immune system – Nov 2022
- Vitamin D, immune System, Infection, and COVID- Video Oct 2022
- Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
- Long-Haul more prevalent among seniors - June - 2022
- Vitamin D, Immune function, and SARS-CoV2 – May 2022
- Innate immune suppression by SARS-CoV-2 mRNA vaccinations - April 2022
- Immune system both activates and uses vitamin D (in brain, fight COVID, etc.) - March 2022
- COVID can be fought by healthy immune systems (vitamins, etc.) - Feb 2022
- Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
- Vaccine definition by the CDC seems to now include Vitamin D - Sept 2021
- Immune system - great 11-minute animated video - Aug 2021
- Vitamin D for infections and COVID (50,000 IU weekly for 3 months) – July 2021
- Vitamin D and COVID-19 both affect immune cells – June 2021
- T-cells need at least 40-50 ng of Vitamin D to fight COVID-19 - June 2021
- COVID-19 activates and Vitamin D de-activates 12 cytokines (mini-review)– May 2021
- Long-haul COVID-19 - another hint that Vitamin D should help - Dec 2020
- Strong innate immune systems do not get viral symptoms (COVID-19) – April 2021
- How healthy innate immune systems adapt to viral mutations - Feb 2021
- immune system charts (vitamin D, virus, mutation, etc)
- 600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
- Ways to boost immune system to fight COVID-19 (no protocol) - Oct 2020
- COVID-19 patients with low vitamin D had far fewer natural killer cells – Dec 2020
- Protect your immune system from COVID-19, flu, colds, etc with 10,000 IU of vitamin D etc. - Nov 2020
- 19X fewer COVID-19 infections if innate immune system activated – trial Oct 21, 2020
- Nutrients etc, which fight viruses and fortify the immune system
- Covid-19, T cells, and Vitamin D
- Mild COVID-19 quickly treated by Zinc lozenges in 4 people – June 6, 2020
- Clear Association between Influenza and low Vitamin D - March 2020
- Immune system is capable of producing 1 Quadrillion unique antibodies - Jan 2019
- Immune system is fortified by micronutrients such as vitamin D – Review Jan 2020
- Vitamin D probably can both prevent Influenza and augment vaccine effectiveness – Aug 2018
- Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
- Immunity increased by Vitamin D via cells and genes (HIV etc.) – March 2018
- Flu
- Congenital Zika Syndrome (more than microcephaly) – Spring 2016
- Dengue fever immune response and micronutrients (vitamins D, E, A, and Zinc, Iron, Chromium) – Nov 2015
- Adaptive immunity (cancer, viruses, autoimmune) and vitamin D – April 2016
- Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009
- Immune response to respiratory viruses – vitamin D connection – review May 2015
- Vitamin D may protect against Ebola
- Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014
VitaminDWiki - COVID fought by 50 ng of Vitamin D
- Is 50 ng of Vitamin D enough to fight COVID - TrialSiteNews - Jan 2024
- COVID etc. prevented and treated with 50,000 IU Vitamin D capsules - July 2022
- Discussion of COVID and 50 ng of Vitamin D (video and transcript)– Dr. Campbell Nov 17, 2021
- COVID probably fought by Vitamin D, might need 50 ng - Dr. Patrick Nov 8, 2021
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- Vitamin D and COVID, review of evidence, loading dose if less than 50 ng - Masterjohn Sept 2021
- T-cells need at least 40-50 ng of Vitamin D to fight COVID-19 - June 2021
- COVID-19 prognostic indicators in plasma extrapolate to zero if Vitamin D is 40 to 80 ng – March 2021
- To protect against COVID-19, how much vitamin D – 20 to 50 ng – March 19, 2021
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