Association of Serum 25-Hydroxyvitamin D with Symptoms of Depression After 6 Months in Stroke Patients.
Neurochem Res. 2014 Aug 26. [Epub ahead of print]
Yue W1, Xiang L, Zhang YJ, Ji Y, Li X.
1Department of Neurology, Tianjin Huanhu Hospital, Tianjin, 300060, People's Republic of China.
Vitamin D levels were measured immediately after the stroke
1 in 3 were depressed 6 months after surviving their stroke
Those with levels < 11 ng were, on average, 10X more likely to be depressed 6 months later
10X was the average. The range of 5X to 29X more likely!
Note also: Depression is strongly associated with low vitamin D
Note also: Depressed are somewhat more likely to get a stroke – see VitaminDWiki below
Our aim was to determine whether there was a relationship between 25-hydroxyvitamin D (25[OH] D) and post-stroke depression (PSD). Two hundred and forty-four ischemic stroke patients admitted to the hospital within the first 24 h after stroke onset were consecutively recruited and followed up for 6 months. Clinical information was collected. Serum 25[OH] D levels were measured at baseline. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression at 6-month after stroke.
At 6-month, 91 patients (37.3 %) showed depression and in 60 patients (24.6 %) this depression was classified as major.
There was a significant difference in median serum 25[OH] D levels between PSD patients and no depression cases [8.3 (IQR, 6.8-9.5) vs. 15.6 (IQR, 13.2-20.3) ng/ml, respectively; P < 0.001].
Serum 25[OH] D levels ≤11.2 ng/ml were independently associated with PSD [odds ratio 10.32, 95 % confidence interval 4.97-28.63; P < 0.001], after adjusting for possible confounders.
Serum 25[OH] D levels reduced at admission was found to be associated with PSD. Additional research is needed on vitamin D supplementation to improve the outcome of patients with PSD.
- Depression category listing with extensive associated searches
- Post stroke depression 9X more likely if low vitamin D – Dec 2014
- Overview Stroke and vitamin D has the following on depression leading to stroke
Article about Brigham Women's Hospital Study which was published in Stroke
"women with a history of depression had a 29 percent higher risk of stroke, even after considering other stroke risk factors."
"The study included more than 80,000 female nurses between the ages of 54 to 79 years old from 2000-06 without a prior history of stroke. "
"More than 1000 cases of stroke were documented among the women during the six years."
- Diseases that may be related via low vitamin D has the following chart: Note that Depression has 5 links to other diseases
- Post Stroke Depression Wikipedia Aug 2014
- Post-stroke depression (PSD) is considered the most frequent and important neuropsychiatric consequence of stroke. Approximately one-third of stroke survivors experience major depression. Moreover this condition can have an adverse effect on cognitive function, functional recovery and survival.