Stroke patients with low vitamin D were 10X more likely to become depressed – Aug 2014

Association of Serum 25-Hydroxyvitamin D with Symptoms of Depression After 6 Months in Stroke Patients.

Neurochem Res. 2014 Aug 26. [Epub ahead of print]
Yue W1, Xiang L, Zhang YJ, Ji Y, Li X.
1Department of Neurology, Tianjin Huanhu Hospital, Tianjin, 300060, People's Republic of China.

VitaminDWiki Summary

Vitamin D levels were measured immediately after the stroke
1 in 3 were depressed 6 months after surviving their stroke
Those with levels < 11 ng were, on average, 10X more likely to be depressed 6 months later
    10X was the average. The range of 5X to 29X more likely!
Note also: Depression is strongly associated with low vitamin D
Note also: Depressed are somewhat more likely to get a stroke – see VitaminDWiki below

Our aim was to determine whether there was a relationship between 25-hydroxyvitamin D (25[OH] D) and post-stroke depression (PSD). Two hundred and forty-four ischemic stroke patients admitted to the hospital within the first 24 h after stroke onset were consecutively recruited and followed up for 6 months. Clinical information was collected. Serum 25[OH] D levels were measured at baseline. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression at 6-month after stroke.

At 6-month, 91 patients (37.3 %) showed depression and in 60 patients (24.6 %) this depression was classified as major.

There was a significant difference in median serum 25[OH] D levels between PSD patients and no depression cases [8.3 (IQR, 6.8-9.5) vs. 15.6 (IQR, 13.2-20.3) ng/ml, respectively; P < 0.001].

Serum 25[OH] D levels ≤11.2 ng/ml were independently associated with PSD [odds ratio 10.32, 95 % confidence interval 4.97-28.63; P < 0.001], after adjusting for possible confounders.

Serum 25[OH] D levels reduced at admission was found to be associated with PSD. Additional research is needed on vitamin D supplementation to improve the outcome of patients with PSD.

PMID: 25154401

See also VitaminDWiki

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See also web

  • Post Stroke Depression Wikipedia Aug 2014
  • Post-stroke depression (PSD) is considered the most frequent and important neuropsychiatric consequence of stroke. Approximately one-third of stroke survivors experience major depression. Moreover this condition can have an adverse effect on cognitive function, functional recovery and survival.

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