Single dose (up to 60,000 IU) vitamin D raised levels in 87 percent of Cystic fibrosis patients – RCT March 2013

Single high-dose oral vitamin D3 (stoss) therapy--a solution to vitamin D deficiency in children with cystic fibrosis?

J Cyst Fibros. 2013 Mar;12(2):177-82. doi: 10.1016/j.jcf.2012.08.007. Epub 2012 Sep 19.
Shepherd D1, Belessis Y2, Katz T2, Morton J2, Field P2, Jaffe A2.

To determine the safety and efficacy of stoss therapy on vitamin D levels over a 12 month period in children with cystic fibrosis and vitamin D deficiency (<75 nmol/L).

Retrospective chart review of 142 paediatric CF patients from 2007 till 2011.

Thirty eight children received stoss therapy and 37 children with vitamin D deficiency were not treated and served as a control group. The stoss treated group had a significant and sustained increase in 25-hydroxyvitamin D levels measured at 1, 3, 6 and 12 months post treatment compared to controls (94.82 ± 41.0 nmol/L, p=0.001; 81.54 ± 24.6 nmol/L, p=0.001; 92.18 ± 36.5 nmol/L, p=0.008 and 64.6 ± 20.0 nmol/L, p=0.006 respectively). At 12 months post intervention, the mean difference in vitamin D levels from baseline between the stoss treated group and controls was significant at 15 nmol/L compared to 5 nmol/L (p=0.038).

Stoss therapy effectively achieves and maintains levels of 25-hydroxyvitamin D greater than 75 nmol/L over 12 months.

PMID: 22998937
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Stoss therapy (Table 1)

25-Hydroxyvitamin D
level (nmol/L)
<3 years 3–12 years >12 years
≤25 200 000 IU 400 000 IU 600 000 IU
25–50 150 000 IU 350 000 IU 500 000 IU
50–75 100 000 IU 200 000 IU 300 000 IU



13% did not respond

VitaminDWiki expects that a different form of vitamin D would have resulted in responses.
  Sublingual,Inaled, Injection topical, patch, gut friendly, etc.
   as well as adding Omega-3 and/or Magnesium

See also VitaminDWiki

Many ways to increase Vitamin D - click on chart for details

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