Shift workers have low vitamin D, poorer sleep, and are more depressed – March 2019

Shift work and depressive symptoms: the mediating effect of vitamin D and sleep quality.

Chronobiol Int. 2019 Mar 7:1-9. doi: 10.1080/07420528.2019.1585367.

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 Download the PDF from VitaminDWiki

Park H1, Suh B1, Lee SJ2.

  • 1 Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital , Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
  • 2 Department of Occupational and Environmental Medicine, College of Medicine , Hanyang University , Seoul , Republic of Korea.


Shift work is associated with vitamin D level, sleep quality, and depressive symptoms. Vitamin D and sleep quality are also associated with depressive symptoms. The purpose of this study was to compare vitamin D level, sleep quality, and depressive symptoms between shift workers and daytime workers and analyze the mediating effect of vitamin D and sleep quality between shift work and depressive symptoms. Among those who participated in the Kangbuk Samsung Health Study in 2012 and 2014, 82,078 cases of full-time workers were analyzed. We evaluated their shift work, vitamin D level, sleep quality, and depressive symptoms with blood samples and questionnaires. Chi-square tests, t-tests, and path statistical analysis were performed. More depressive symptoms, lower vitamin D levels, and poorer sleep quality were associated with shift work. According to a path analysis, shift work had both a direct effect and an indirect effect on depressive symptoms, each mediated by sleep quality and vitamin D level. When a multigroup analysis was conducted for each sex, paths containing sleep quality were more significant in female shift workers than male shift workers; paths involving vitamin D did not differ between sexes. To assess depression risk in shift workers, evaluating vitamin D level and sleep quality is essential. Also, sleep problems are more prevalent in female compared to male shift workers with respect depression prevalence.

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