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- Vitamin D and SARS-CoV2 infection, severity and mortality: A systematic review and meta-analysis
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43 Virus Meta-analyses - VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos
Vitamin D and SARS-CoV2 infection, severity and mortality: A systematic review and meta-analysis
PLoS One. 2022 Jul 6;17(7):e0268396. doi: 10.1371/journal.pone.0268396
Oriana D'Ecclesiis 1, Costanza Gavioli 2, Chiara Martinoli 1, Sara Raimondi 1, Susanna Chiocca 1, Claudia Miccolo 1, Paolo Bossi 3, Diego Cortinovis 4, Ferdinando Chiaradonna 5, Roberta Palorini 5, Federica Faciotti 1, Federica Bellerba 1, Stefania Canova 4, Costantino Jemos 6, Emanuela Omodeo Salé 6, Aurora Gaeta 1, Barbara Zerbato 5, Patrizia Gnagnarella 2, Sara Gandini 1 Italy
To assess the evidence on SARS-CoV2 infection and Covid-19 in relation to deficiency and supplementation of vitamin D, we conducted a systematic review up to April 2021. We summarised data from 38 eligible studies, which presented risk estimates for at least one endpoint, including two RCT and 27 cohort-studies: 205565 patients with information on 25OHD status and 2022 taking vitamin D supplementation with a total of 1197 admitted to the ICU or who needed invasive mechanical ventilation or intubation and hospital stay, and more than 910 Covid-19 deaths. Primary outcomes were severity and mortality and the main aim was to evaluate the association with vitamin D supplementation. Random effects models showed that supplementation was associated with a significant lower risk of both Covid-19 severe disease (SRR 0.38, 95% CI 0.20-0.72, 6 studies) and mortality (SRR 0.35, 95% CI 0.17-0.70, 8 studies). There were no statistically significant dose differences between studies: summary estimates with regular doses remain statistically significant, suggesting that higher doses are not necessary. For patients on vitamin D supplementation, a greater reduction in mortality risk emerged in older individuals and at higher latitudes. Regarding the quality of studies, assessed using the New Castle-Ottawa quality scale, the analysis revealed in most cases no statistically significant differences between low, medium or high quality studies. We found significant associations of vitamin D supplementation with Covid-19, encompassing risks of disease worsening and mortality, especially in seasons characterized by 25OHD deficiency and with not severe patients. Dedicated randomized clinical studies are encouraged to confirm these results.
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43 Virus Meta-analyses This list is automatically updated
- Vaccinations did not stop COVID (68 studies) – meta-analysis May 2023
- Influenza risk cut in half by the only trial giving enough vitamin D for body weight – meta-analysis Jan 2022
- Multiple Vitamin D doses reduced COVID ICU by 2.5 X , Mech. Ventilation by 5.5 X – meta-analysis May 2024
- COVID death rate in hospital halved if take any amount of vitamin D for any length of time – meta-analysis May 2024
- COVID and Vitamin D: 2X more likely to die if low, 2X more likely to survive if supplement – umbrella meta-analysis April 2024
- COVID fought by Vitamin D: 2.3X less likely to die of COVID if supplemented, 1.9 X less likely to become infected – meta-analysis March 2024
- COVID Vaccinations increased risk of cardiac deaths in youths by 19% - Aug 2023
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- Yet another reason to take Vitamin D while pregnant – fight COVID - meta-analysis May 2023
- COVID death 1.5 X less likely if high vitamin D, emergency D (50K to 100K) is great – meta-analysis March 2023
- COVID ICU 3X less-likely if take any amount and type of Vitamin D – meta-analysis Jan 2023
- COVID and Vitamin D: any amount of D, at any time, for any duration reduced ICU - meta-analysis Dec 2022
- Worse COVID during 3Q pregnancy if 2.5 ng lower Vitamin D – meta-analysis Sept 2022
- Severe COVID 2.6 X less likely if supplement with Vitamin D – 26th meta-analysis - July 2022
- COVID Long-Haul prevalence increases with time: 50% at 4 months - meta June 2022
- COVID test positive is about half as likely if have Vitamin D – 24th meta-analysis - Jan 2022
- Small amounts of Vitamin D reduce Influenza risk by 22 percent (loading dose is far better) – meta-analysis Jan 2022
- Vitamin D fights COVID (54 studies of 1,400,000 people) – 23rd meta-analysis - Dec 2021
- COVID-19 treated by Vitamin D (reduce ICU by 3X) - 22nd meta-analysis - Dec 29, 2021
- COVID-19 death increased 2X if low Vitamin D (less than 10 to less than 30 ng) – 21st meta-analysis Dec 2021
- COVID-19 risk reduced by vitamin D supplementation – umbrella review of 7 meta-analysis – Oct 2021
- COVID-19 treated by Vitamin D (example: ICU reduced by 5X) – 20th meta-analysis Oct 13, 2021
- Severe COVID-19 2.5 X more likely if low vitamin D (23 studies) – 19th meta-analysis Oct 2021
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- COVID-19 death 1.6 X more likely if low vitamin D (24 studies) – 17th meta-analysis Aug 2021
- Severe COVID-19 5X more likely if low vitamin D (23 studies) – 16th meta-analysis July 2021
- Severe COVID-19 3.5 more likely if low vitamin D (30 studies) – meta-analysis July 2021
- COVID-19 patients who had supplemented with Vitamin D were 3X less likely to enter ICU – June 2021
- Low Calcium associated with severe COVID-19 – several studies
- COVID-19 mortality 3X more likely if low vitamin D (999,179 people) – meta-analysis March 29, 2021
- COVID-19 was 2.6X more severe if very low Vitamin D (43 studies) – meta-analysis March 26, 2021
- Low Vitamin D associated with 2.7X more severe COVID-19 – 12th MA March 5, 2021
- Vitamin D supplementation fights COVID-19 – 11th meta-analysis Jan 24, 2021
- 3.7 X less likely to die of COVID-19 if supplemented with Vitamin D - meta-analysis Jan 5, 2021
- Less likely to test positive for COVID-19 if higher Vitamin D – meta-analysis Jan 6, 2021
- Vitamin D reduces COVID-19 by 80 percent - anonymous meta-analysis - Jan 5, 2021
- COVID-19 1.7X more likely to be severe if low Vitamin D - meta-analysis Oct 2020
- Low Vitamin D associated 1.8X increased risk of COVID-19 death in hospital – meta-analysis Nov 4, 2020
- Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020
- Prudent to consider that Vitamin D has a role in COVID-19 – meta-analysis – Aug 7, 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Hepatitis B patients have 2 ng lower level of Vitamin D – meta-analysis June 2019
- Influenza Vaccination not benefited by lowish levels of vitamin D – meta-analysis March 2018
VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos
As of March 31, 2024, the VitaminDWiki COVID page had: trial results, meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, All 26 COVID risk factors are associated with low Vit D, Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 166 COVID Clinical Trials using Vitamin D (Aug 2023) Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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