Rates of some newly diagnosed Cancers increased with higher Vitamin D (217,000 Danes) – Jan 2019

Vitamin D levels and Cancer Incidence in 217.244 individuals from Primary Health Care in Denmark

International Journal of Cancer, https://doi.org/10.1002/ijc.32105
Fie Juhl Vojdeman PhD Christian Medom Madsen MD Kirsten Frederiksen PhD Darshana Durup PhD Anja Olsen PhD Louise Hansen PhD …


Wonder why a few cancers show increased rates with higher levels of vitamin D
They excluded those people who already had (some form of) Cancer.
Is this exclusion a clue?

Cancer category starts with the following

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

 Download the Sci-Hub via PDF from VitaminDWiki

The following charts are probably for
  Melanoma, Non-melanoma, Prostate, Hematological, Non-Hodgkin, Lymphoma, Lung
(the figures in the submitted PDF was not clearly labeled)

Vitamin D has been linked to cancer development in both pre‐clinical and epidemiological studies. This study examines the association between serum levels of vitamin D and cancer incidence in the Capital Region of Denmark. Individuals who had vitamin D analyzed at The Copenhagen General Practitioners Laboratory between April 2004 and January 2010 were linked to Danish registries with end of follow‐up date at Dec 31st 2014, excluding individuals with pre‐existing cancer. Cox regression models adjusted for age in one‐year intervals, sex, month of sampling, and Charlson Comorbidity Index were applied. The study population of 217,244 individuals had a median vitamin D level of 46 nmol/L (IQR 27‐67 nmol/L).
Non‐melanoma skin cancer was the most frequent form of cancer, followed by breast‐, lung‐, and prostate cancers.
No associations were found between increments of 10nmol/L vitamin D and incidence of breast, colorectal, urinary, ovary or corpus uteri cancer.
However, higher levels of vitamin D were associated with higher incidence of

  • non‐melanoma (HR 1.09 [1.09‐1.1]) and
  • melanoma skin cancer (HR 1.1 [1.08‐1.13]) as well as
  • prostate (HR 1.05 [1.03‐1.07]) and
  • hematological cancers (HR 1.03 [1.01‐1.06]),

but with lower incidence of

  • lung cancer (HR 0.95 [0.93‐0.97]).

In this study, vitamin D levels are not associated with the incidence of several major cancer types, but higher levels are significantly associated with a higher incidence of skin, prostate, and hematological cancers as well as a lower incidence of lung cancer. These results do not support an overall protective effect against cancer by vitamin D.

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