Emerging paradigm shift towards proactive topical treatment of psoriasis: A narrative review
Dermatol Ther. 2021 Aug 21;e15104. doi: 10.1111/dth.15104 publisher rents the PDF for $16
Kim A Papp 1, Gurbir Dhadwal 2, Melinda Gooderham 3, Lyn Guenther 4, Irina Turchin 5, Marni Wiseman 6, Jensen Yeung 7
Note by Founder of VitaminDWiki:
Topical Vitamin D works great for many skin problems, not just psoriasis. Vitamin D oil or nanoemulsion (2,000 IU per drop), and Vitamin D Aloe Cream (10,000 IU per pump) both work within days
Psoriasis (PsO) requires safe and effective long-term management to reduce the risk of recurrence and decrease the frequency of relapse. Topical PsO therapies are a cornerstone in the management of PsO though safety concerns limit the chronic, continuous use of topical corticosteroids and/or vitamin D3 analogues.
Evidence-based guidelines on optimal treatment targets and maintenance therapy regimens are currently lacking. This review explores the evidence supporting approaches to maintenance topical therapy for PsO including
- continuous long-term therapy,
- chronic intermittent use,
- step-down therapy,
- sequential or pulse therapy regimens, and
- proactive maintenance therapy.
Several unaddressed questions are discussed including how and when to transition from acute to maintenance therapy, strategies for monitoring long-term treatment, the role of topical maintenance therapy in the context of systemic and biologic therapies, risks of maintenance therapy, prescribing a topical preparation suitable for patients' preferences and skin type, and key concepts for patient education to maximize long-term outcomes.
Overall, emerging evidence supports a paradigm shift towards proactive treatment once skin is completely clear as a strategy to enhance disease control without compromising safety.
Psoriasis in VitaminDWiki
Some of the- Psoriasis is most strongly associated with low vitamin D (15 things were evaluated) – July 2022
- Long-term Psoriasis cured by 30,000 to 60,000 IU of Vitamin D daily (pictures and video) – early 2022
- Psoriasis paradigm shift – use topicals, like Vitamin D – Aug 2021
- Low Vitamin D plus psoriasis equals 8 times more likely to die – Dec 2020
- UV has treated psoriasis for over a century, guidelines finally agreed upon – Aug 2019
- Psoriasis severity associated with low vitamin D (10 studies) – meta-analysis Jan 2018
- Psoriasis reduced for those getting Vitamin D levels above 50 ng – RCT Feb 2018
- 35,000 IU vitamin D daily for 6 months helped ALL psoriasis suffers (106 ng) – Brazil March 2013
TOP articles in Forms of Vitamin D:
- Fat-soluble Vitamins go thru the slow lymph system
- Olive oil problem with Vitamin D (again) - Nov 2023
- Vitamin D which dissolves in mouth for those having poor response due to poor guts, HSCT etc.- June 2023
- Vitamin D: not one size, type, form, route for all - Jan 2022
- Nanoemulsion Vitamin D faster and better (paywall) – RCT Dec 2021
- Psoriasis paradigm shift – use topicals, like Vitamin D – Aug 2021
- Nanoemulsion Vitamin D is faster and better - many studies
- Vitamin D – food fortification around the world, types of microencapsulation – Feb 2020
- Nanoemulsion vitamin D is again found to be the best liquid form (for rats in this case) – June 2019
- Bioavailability of nanoemulsion formulations of Vitamin D3 – Nov 2019
- Topical Vitamin D provides more benefits than oral sometimes - many studies
- Vitamin D nanoemulsion etc. for fortification, pills, injections, topical and cancer – July 2019
- Vitamin D nanoemulsion corrected deficiency and improved bones in 1 week (high dose in rats) – Jan 2019
- Nanoemulsion Vitamin D may be a substantially better form
- The lungs can activate vitamin D locally – a Vitamin D inhaler may help lungs – Aug 2016
- Vitamin D sprayed inside cheeks (buccal spray) - several studies
- Getting Vitamin D into your body
- Topical vitamin D raised blood level to 38 ng (used Aloe Vera gel) – RCT March 2014
- Spray vitamin D inside cheek in case of emergency - Nov 2012
| 2951 visitors, last modified 30 Dec, 2023, |