Prenatal Vitamin B12 and Children's Brain Development and Cognitive, Language and Motor Outcomes: A Scoping Review
Children 2024, 11,58. https://doi.org/10.3390/children11050558
Fasika Jembere -1 and Deborah Dewey 2'3,4'5'* dmdewey@ucalgary.ca
Undergraduate Medical Education, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada; fasika.jembere1@ucalgary.ca
Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada Owerko Centre, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 1N4, Canada
Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada
Hotchkiss Brain Institute and Mathison Centre for Mental Health and Research, University of Calgary, Calgary, AB T2N 4N1, Canada
Adequate maternal nutrient intake of vitamin B12 is critical to fetal brain development and subsequent neurodevelopmental outcomes. We conducted a scoping review to map the current state of knowledge from human epidemiological studies on the associations between maternal vitamin B12 during pregnancy and children's brain, cognitive, language, and motor development to identify gaps in the literature and suggest directions for future research. PubMed and OVID MEDLINE were searched. Search terms were vitamin B12, prenatal or maternal, neurodevelopment or cognitive development or brain. Animal studies were excluded. In total, 148 publications were identified, of which 19 met our inclusion criteria: (1) maternal vitamin B12 assessed via a measure of status, dietary intake, supplementation, or deficiency; and (2) an outcome related to brain development or cognitive, language, or motor development in children less than 18 years of age was assessed. This scoping review suggests that evidence supporting a relationship between maternal vitamin B12 during pregnancy and children's neurodevelopmental outcomes is inconclusive. Further longitudinal research is needed to clarify the effects of maternal vitamin B12 supplementation, status, and intake on children's brain development and neurodevelopmental outcomes.
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VitaminDWiki – Vitamin B12 category contains
Vitamin B12 is not a cofactor of Vitamin D, but it is often needed with Vitamin D
Surfing the web finds
- B12 deficiency increases with age
- B12 appears to have no toxic upper limit
- Some people get frequent B12 injections or I.V to restore levels
- Injection probably be needed
- Only a small portion of B12 taken orally gets into the bloodstream
- Sublingual B12 does not have that problem
- Vitamin B12 – great improvements with nano forms – March 2021
- B12 is stored in the liver – half-life of > 2 years - But. Dr. Greger says to take it weekly or daily
- B12 deficiency symptoms include poor gut - which can reduce uptake of Vitamin D
- unless use gut-friendly forms of Vitamin D, including topical
- B12 can be supplemented via pills, sublingual, transdermal patch, injection, emulsion, and spray
- As with Vitamin D, a massive (loading) dose can restore levels quickly
- Nano forms of B12 are more bio-available - as with many other supplements
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