Clin Dermatol. 2016 Sep-Oct;34(5):548-55. doi: 10.1016/j.clindermatol.2016.05.004. Epub 2016 May 20.
Juzeniene A1, Grigalavicius M2, Juraleviciute M2, Grant WB3.
1Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310 Oslo, Norway. Electronic address: Asta.juzeniene@rr-research.no.
2Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310 Oslo, Norway.
3Sunlight, Nutrition, and Health Research Center, San Francisco, CA.
The skin is the site for the photosynthesis of vitamin D and is a target tissue for the active metabolite of vitamin D. An increasing body of evidence indicates that vitamin D produced during phototherapy may be responsible for the positive effects observed during treatment of some skin diseases. Topical or oral application of vitamin D derivatives are used alone or with phototherapy. This paper reviews what is known about the use of phototherapy to enhance vitamin D levels, the use of vitamin D analogues with phototherapy, the efficacy of combination therapies, and controversies regarding some of the outcomes. Vitamin D can play a beneficial role in treating psoriasis, even though the exact role of vitamin D in the pathogenesis and severity of psoriasis remains unclear. The role of vitamin D in vitiligo, atopic dermatitis, polymorphic light eruption, and mycosis fungoides must be further investigated.
Copyright © 2016 Elsevier Inc. All rights reserved.
PMID: 27638432 DOI: 10.1016/j.clindermatol.2016.05.004
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