Vitamin D receptor gene variants in Parkinson’s disease patients
Egyptian Journal of Medical Human Genetics, http://dx.doi.org/10.1016/j.ejmhg.2016.08.004
Rokhsareh Meamara, b, Seyed Morteza Javadiradc, Niloofar Chitsaza, Mojgan Asadiana, Mahdi Kazemib, Maryam Ostadsharifd, e, , ,
| Allele | PD Risk |
| ApaI a | 1.85 |
| FokI f | 2.46 |
| Aa heterozygous of ApaI vs AA homozygous | 7.44 |
See also VitaminDWiki
The items in both Parkinson's Disease and Vitamin D Receptor categories are listed here:
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- Parkinson’s Disease, low vitamin D and Vit. D genetics – Jan 2023
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Overview Parkinson's and Vitamin D contains the following summary
- Vitamin D associated with Parkinson’s Disease in 55 studies, more studies needed- March 2022
- Parkinson's category has
117 studies - Parkinson’s Disease and Vitamin D – review of 52 studies – May 2022
- Parkinson patients: 60 % taking Vitamin D – Dec 2019
- Low Vitamin D increases Parkinson's by 3X– July 2010 "only" a 30 year test, need more study
- Parkinson's disease prevented by Vitamin D, but small doses do not treat it - Aug 2023
- 10 clinical trials for PD with vitamin D intervention as of June 2023
- Parkinson’s Disease Summer School – alternative therapies included 60-80 ng of Vitamin D – Sept 2019
- Associated with PD are: Meta-analyses (
12 ), Cognition ( 24 studies), Multiple Sclerosis ( 18 studies), VIRUS ( 4 studies), Omega-3 ( 3 studies), Vitamin D Receptor ( 11 studies) - Note by the Founder of VitaminDWiki: I have twice recommended lots of Vitamin D to treat PD. Both got much better, but one had his doctor him cut back to just 2,000 IU. All of his recovery got reversed. With lots of vitamin D he could sing and bike, but now he can barely talk or walk
Vitamin D Receptor category listing has530 items along with related searches,
and the following observationVitamin D ==> Calcidiol = measured Vitamin D ==> Calcitriol ==> Vitamin D Receptor ==> Cell
Thus you can have a good measured level of vitamin D,
but the Cell does not get as much due to poor Vitamin D ReceptorDownload the PDF from VitaminDWiki
Background: Vitamin D plays an important role in neurodegenerative disorders as a crucial neuro-immunomodulator. Accumulating data provide evidences that vitamin D receptor (VDR) gene is a candidate gene for susceptibility to Parkinson’s disease (PD).
Aim: To find out whether the risk of the development of sporadic PD might be influenced by VDR gene polymorphisms in an Iranian population or not.
Subjects and methods: A genetic study was conducted to investigate the relationship between VDR gene polymorphisms and the severity of PD. Fifty-nine PD patients and 53 matched-healthy controls were genotyped using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) analysis. For this purpose, four single nucleotide polymorphisms (SNPs) in VDR gene including FokI T > C (rs 10735810), BsmI A > G (rs 1544410), ApaI A > C (rs 7975232), and TaqI C > T (rs 731236) have been evaluated.
Results: Our genotyping studies revealed that holding ApaI a allele and FokI f allele could significantly increase the risk of developing Parkinson’s disease 1.85 and 2.46 times, respectively (p = 0.023 and 0.008). Moreover, Aa heterozygous of ApaI also shows a significantly elevated risk of developing PD when compared to AA homozygous (OR = 7.44, p = 0.005). For BsmI and TaqI polymorphisms, no significant difference in genotype or allele distribution was found between PD patients and the controls. Moreover, in this study, no significant association was found between different genotypes and Hoehn & Yahr staging and Unified Parkinson Disease Rating Stage (UPDRS) rating scale.
Conclusion: This study demonstrates a possible association between the VDR FokI and ApaI polymorphism and PD, indicating that VDR polymorphisms may change genetic susceptibility to sporadic PD in the Iranian population.
See also web
- Vitamin D receptor gene polymorphisms and cognitive decline in Parkinson's disease
- The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease - Sept 2020
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