Pancreatic cancer risk reduced 25 percent by just 10 micrograms of Vitamin D or Vitamin B12 – meta-analysis March 2018

Vitamin intake and pancreatic cancer risk reduction: A meta-analysis of observational studies.

Medicine (Baltimore). 2018 Mar;97(13):e0114. doi: 10.1097/MD.0000000000010114.
Liu Y1, Wang X2, Sun X3, Lu S4, Liu S.
1 Department of Oncology, The 3rd Affiliated Hospital, Qiqihar Medical University, Qiqihar.
2 Heilongjiang Institute of Dermatology and Sexually Transmitted Disease, Harbin.
3 Department of Radiology, The 3rd Affiliated Hospital, Qiqihar Medical University.
4 Department of Ultrasound, The 2nd Affiliated Hospital, Qiqihar Medical University.

VitaminDWiki

Comments by Henry Lahore, founder of VitaminDWiki

This study shows that the people who got 10 micrograms of Vitamin D or Vitamin B12 had a 25% reduction in risk of getting Pancratic Cancer. The taking of the vitamins might have resulted in the decreased risk, but perhaps taking the vitamins was associated with some other health promotion behaviour which resulted in less pancratic cancer.
Suspect that taking both vitamins will result in even less pancratic cancer
Suspect that taking more of each vitamin would futher reduce the risk of pancreatic cancer

See also VitaminDWiki

Pancreatic cancer 55 percent less likely if optimal vitamin D (vs low) – Nov 2017 - much higer than 10 micrograms per day
Vitamin D and Pancreatic Cancer Risk - No U-Shaped Curve - Mar 2012
No U-shaped curver means that there is no increased risk of PC if take more vitamin D
Restoring vitamin D levels to Pancreatic patients required up to 20000 IU daily – May 2012
B12 category listing has 57 items along with related searches

Download the PDF from VitaminDWiki

BACKGROUND:
The relationship between vitamin intake and pancreatic cancer (PC) risk is disputed. We aimed to investigate the association between vitamin intake and the risk of PC via meta-analysis.

METHODS:
We conducted a meta-analysis of studies concerning vitamin intake and the risk of PC from EMBASE, MEDLINE, and Cochrane Library. The search yielded 25 correlative studies including 1,214,995 individuals. The relative risks (RR) were examined by a random-effect model or fixed-effect model. Subgroup analysis, dose-response analysis, sensitivity analysis, meta-regression, and publication bias analysis were used to analyze studies.

RESULTS:
The RR of PC in the highest vitamin intake group was 0.90 (95% confidence interval, 0.83-0.98) compared with that in the lowest vitamin intake in the prospective studies. Different increments of vitamin intake and the risk of PC were examined with dose-response analysis, and a decrease in the risk of PC was observed with vitamin D (25%) and vitamin B12 (27%).

CONCLUSIONS:
This meta-analysis found that vitamin intake can decrease the risk of PC, particularly vitamin D and vitamin B12.

PMID: 29595633 DOI: 10.1097/MD.0000000000010114

From Discussion section of PDF

"This meta-analysis included more than 1.2 million human participants and 8000 PC cases. We found that vitamin consumption can moderately decrease the risk of PC. Daily consumption of 10mg/d of vitamin B12 or vitamin D can dramatically reduce the incidence of PC, 27% for vitamin B12 and 25% for vitamin D in the dose–response meta-analysis."