Obese children probably need more than 25,000 IU of vitamin D weekly – July 2014

Efficacy and Tolerability of a High Loading Dose (25,000 IU Weekly) Vitamin D3 Supplementation in Obese Children with Vitamin D Insufficiency/Deficiency

Hormone Research in Paediatrics Vol. 82, No. 2, 2014
Radhakishun N.N.E. · van Vliet M. · Poland D.C.W. · Weijer O. · Beijnen J.H. · Brandjes D.P.M. · Diamant M. · von Rosenstiel I.A.

Background: The recommended dose of vitamin D supplementation of 400 IU/day might be inadequate to treat obese children with vitamin D insufficiency. Therefore, we tested the efficacy and tolerability of a high loading dose vitamin D3 supplementation of 25,000 IU weekly in multiethnic obese children, 8-18 years of age, with vitamin D insufficiency/deficiency. Methods: Fasting blood samples were drawn for the assessment of vitamin D. Vitamin D-insufficient/-deficient children (<50 nmol/l) were supplemented, using a high loading dose of 25,000 IU weekly, and measured again 9 weeks later. Vitamin D supplementation was considered effective and tolerable when an increase to vitamin D sufficiency (25(OH)D >50 nmol/l) was reached in >75% without side effects nor reaching toxic levels.

Results: In total, 109 children (mean ± SD age 11.1 ± 3.0, 34.2% boys, 90.8% obese) received vitamin D supplementation. In 84.4% of the children, the vitamin D status improved from insufficiency/deficiency (<50 nmol/l) to sufficiency (≥50 nmol/l). The majority of children that did not reach vitamin D sufficiency reported non-compliance. No side effects were reported, and the highest level reached was far below the threshold for toxicity.

Conclusion: A high loading dose vitamin D3 supplementation is effective and well-tolerated in our cohort of multiethnic obese children with vitamin D insufficiency/deficiency. © 2014 S. Karger AG, Basel

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Comments by VitaminDWiki

As with many other studies, this study would have better success if used any combientaion of the following

  1. Had extended the trial for more than 9 weeks
  2. Had used a loading dose
  3. Had used more than 25,000 IU

The lowest optimum level is 40 ng, Their 20 ng goal provides very few health benefits

See also VitaminDWiki

Pages listed in BOTH the categories Infant/Child and Obesity


Overview Obesity and Vitamin D contains the following summary

Obese need more Vitamin D
Image

  • Normal weight     Obese     (50 ng = 125 nanomole)

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