Gestational Vitamin D and Offspring Risk of Multiple Sclerosis: A Systematic Review and Meta-Analysis
Annals of Epidemiology, https://doi.org/10.1016/j.annepidem.2019.12.010
ElizabethJasperMS1NicholeNideyMS1Marin L.SchweizerPhD123KelliRyckmanPhD1
Items in both categories MS and Pregnancy are listed here:
- Multiple Sclerosis 40 percent more likely if mother had low vitamin D – meta-analysis Jan 2020
- High-dose Vitamin D for Multiple Sclerosis is OK while pregnant – Sept 2019
- Extended breastfeeding cut in half the risk of Multiple Sclerosis – July 2017
- Multiple Sclerosis risk reduced 30 percent by each additional 10 ng of vitamin D at birth (1500 Danes) – Jan 2017
- A gestational dose of vitamin D per day keeps the MS doctor away (2X reduction) – Nov 2016
- Multiple Sclerosis 2X more likely if vitamin D deficient as a fetus decades earlier – May 2016
- No multiple sclerosis relapses during pregnancy if 50,000 IU of Vitamin D weekly – RCT April 2015
- Season of birth associated with pneumonia (10 pcnt) and multiple sclerosis (30 pcnt) – May 2013
- Multiple Sclerosis more likely if mother had less than 25 ng of vitamin D – Nov 2012
- Multiple Sclerosis 23 percent more likely if born in April vs. Oct – meta-analysis Nov 2012
- High vitamin D in moms decreased MS incidence in daughters by 40% – July 2011
Items in both categories MS and Meta-analyses are listed here:
- Multiple Sclerosis treatment not helped by small doses of vitamin D (yet again) – meta-analysis Jan 2024
- Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020
- Multiple Sclerosis: 10 percent fewer relapses for each 10 ng higher level of vitamin D – Meta-analysis April 2020
- Multiple Sclerosis 40 percent more likely if mother had low vitamin D – meta-analysis Jan 2020
- Risk of Multiple Sclerosis varies with the Vitamin D Receptor – meta-analysis Dec 2019
- MS not treated by Vitamin D (a few old studies using small doses) – Meta-analysis July 2018
- Multiple Sclerosis treated when use high doses of vitamin D – meta-analysis May 2018
- Fewer Multiple Sclerosis lesions when supplemented with Vitamin D – meta-analysis May 2017
- Multiple Sclerosis and small doses of Vitamin D – meta-review March 2016
- Multiple sclerosis patients have 15 ng lower levels of vitamin D – meta-analysis June 2014
- Multiple Sclerosis and the Vitamin D Receptor – meta-analysis July 2014
- Multiple Sclerosis: number needed to treat with vitamin D may be as low as 1.3 – Meta-analysis Oct 2013
- No association between Multiple Sclerosis relapses and being treated with vitamin D–meta-analysis May 2013
- Multiple Sclerosis 23 percent more likely if born in April vs. Oct – meta-analysis Nov 2012
Purpose: Our objective was to systematically review and meta-analyze studies that assessed the association between gestational vitamin D levels and risk of multiple sclerosis (MS) in offspring.
Methods
Embase and Pubmed databases were searched from inception to May 2018. Original, observational studies that investigated both clinically defined MS (in offspring) and vitamin D levels in utero or shortly after birth were included. Two reviewers independently abstracted data and assessed the quality of studies using the Newcastle-Ottawa Quality Assessment Scale. Summary effect estimates and 95% confidence intervals were calculated with random effects models using inverse variance weighting. Determinants of heterogeneity were evaluated.
Results
Four case-control studies of moderate to low risk of bias were included. Summary effect estimates of the effect of higher levels of gestational vitamin D on risk of offspring MS demonstrated a significant protective effect in random-effects (OR: 0.63, 95% CI: 0.47, 0.84) models and in a stratified analysis based on study quality. Factors identified as determinants of heterogeneity were the definitions of vitamin D deficiency, the characteristics of study participants, and the quality of the study.
Conclusions
Sufficient levels of vitamin D during pregnancy may be protective against offspring’s development of multiple sclerosis later in life.