More Vitamin K associated with fewer COVID-19 problems - April 25, 2020

Reduced Vitamin K Status as a Potentially Modifiable Prognostic Risk Factor in COVID-19

Preprint speculates that supplemening Vitamin K would decrease COVID-19 problems by decreasing clotting by Cytokine storms
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Introduction: Coronavirus 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2. The majority of patients have at most mild symptoms, however, a significant proportion develops respiratory failure. COVID-19 may also progress beyond the lungs. Coagulopathy and thromboembolism are prevalent in severe COVID-19 and relate to decreased survival. Coagulation is an intricate balance between clot promoting and dissolving processes in which vitamin K plays a well-known role. We hypothesized that vitamin K status is reduced in patients with severe COVID-19.

Methods: Vitamin K status was assessed by measuring desphospho-uncarboxylated matrix Gla protein (dp-ucMGP; inversely related to vitamin K status) and the rate of elastin degradation by measuring desmosine. We included 123 patients who were admitted with COVID-19 and 184 controls.

Results: Dp-ucMGP levels were significantly elevated in COVID-19 patients (1,673Å}1,584 pmol/L) compared to controls (536±291 pmol/L; p<0.0005). Dp-ucMGP levels were significantly higher in COVID-19 patients with unfavorable outcome compared to those with less severe disease. Furthermore, dp-ucMGP and desmosine levels were significantly associated (r=0.65; p<0.0005).

Conclusions: Vitamin K status was reduced in patients with COVID-19 and related to poor prognosis.
Also, low vitamin K status seems to be associated with accelerated elastin degradation.
An intervention trial is now needed to assess whether vitamin K administration improves outcome in patients with COVID-19.


Overview Vitamin K and Vitamin D contains the following summary

Vitamin K2 is similar to D3 in many ways

  1. Both vitamins were initially confused with its lesser form (D2 ==> D3, K1 ==> K2)
  2. Both vitamins appear to influence health in large number of ways
  3. Both vitamins in the body are about 1/10 that of a century ago
    Example: Grass-fed beef has a lot more K2, D3, and Magnesium
  4. Need very little of both vitamins: <1 milligram daily
  5. When Vitamin D3 is increased, it appears that Vitamin K2 should also be increased
  6. Vitamin K2 understanding and research is about 20 years behind that of Vitamin D3
    One of the reasons: No simple blood test for K2 as of Jan 2020


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Note: it appears that Vitamin K supplementation provides clotting benefits within weeks

Perhaps you should start taking Vitamin K if get COVID-19 symptoms


Authors were concerned that increasing Vitamin K increases Hypertension and Diabetes

Items in both categories Vitamin K and Hypertension are listed here:

Items in both categories Vitamin K and Diabetes are listed here:



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