Miscarriages strongly associated with poor placental, decidua gene which locally activates Vitamin D – Dec 2016

Women with Recurrent Miscarriage Have Decreased Expression of 25-Hydroxyvitamin D3-1α-Hydroxylase by the Fetal-Maternal Interface.

PLoS One. 2016 Dec 29; doi: 10.1371/journal.pone.0165589. eCollection 2016.
Wang LQ1,2, Yan XT1, Yan CF3, Zhang XW1,3, Hui LY4, Xue M5, Yu XW1.
1Department of Obstetrics and Gynecology in First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
2Nursing Department in Xi'an Medical College, Xi'an, China.
3Reproductive Center in Fourth Hospital of Xi'an, Xi'an, China.
4Laboratory Department in First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
5Clinical Sciences Research Lab, Translational Medicine Section, Division of Biomedical Sciences, Warwick Medical School, University of Warwick, University Hospital, Coventry, United Kingdom.

VitaminDWiki Summary

Facts about Vitamin D activation

  • Vitamin D must be activated before a majority of the benefits can be realized
  • Vitamin D can be activated by Liver & Kidney and put into the bloodstream
  • Vitamin D can also be activated locally by most tissues in the body
    Local activation is not detected by Vitamin D tests
  • Vitamin D is activated by the fetus sometime during gestation

Possibilities

  1. Placenta itself needs activated vitamin D all during gestation
  2. Fetus needs activated vitamin D before it’s liver and kidneys start functioning
       during the time in which miscarriages typically occur

CYP27B1 RNA

Tissues Control Primary miscarriage, Recurrent miscarriage P
Villous 1.20 0.81 0.40 0.000
Decidual 1.35 1.20 0.44 0.003

Easy options to avoid miscarriages due to CYP27B1 restriction

  1. Increase blood-levels of Vitamin D
    e.g. Increase some/all of vitamin D supplements, sunshine, UV, Magnesium, Boron, Omega-3
  2. Increase Vitamin D Receptor (which results in more Vitamin D getting into cells)
    See VDR below in this window

36+ VitaminDWiki pages have MISCARRIAGE in the title

This list is automatically updated

Items found: 37
Title Modified
Miscarriage and low Vitamin D – many studies 03 Apr, 2024
Accutane for acne associated with birth defects, abortions - April 2024 02 Apr, 2024
Miscarriage (Recurrent Spontaneous) associated with poor CYP27B1 gene - Jan 2024 01 Feb, 2024
Recurrent miscarriages decreased by increased Vitamin D levels - Jan 2024 29 Jan, 2024
Miscarriage 2.5X more likely if second-hand smoke and low vitamin D – Sept 2022 06 Sep, 2022
Miscarriage 1.6 X more likely if low vitamin D – meta-analysis May 2022 09 Jun, 2022
Recurrent Miscarriage 4X more likely if low vitamin D – meta-analysis June 2022 07 Jun, 2022
Recurrent pregnancy loss (miscarriage) risk should be reduced by vitamin D, vitamin B12 – March 2021 24 Dec, 2021
Researchers found flu vaccine increased miscarriage risk by 7X -Sept 2017 24 Dec, 2021
Recurrent miscarriage associated with low Vitamin D – Nov 2013 24 Dec, 2021
Recurrent pregnancy loss (miscarriage) is associated with low vitamin D in 6 ways – March 2021 25 Mar, 2021
Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019 26 Feb, 2021
Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020 15 Feb, 2020
Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017 12 Nov, 2019
Miscarriage 32 percent more likely if work night shift (probably low Vitamin D) – April 2019 05 Apr, 2019
Miscarriage 2 times more likely if low vitamin D – meta-analysis May 2017 05 Apr, 2019
Miscarriage 10 percent more likely for each 10 ng less vitamin D at preconception – May 2018 01 Aug, 2018
More pregnancies and fewer abortions when Omega-3 was added (cows in this case) July 2018 31 Jul, 2018
Miscarriages strongly associated with poor placental, decidua gene which locally activates Vitamin D – Dec 2016 28 Jul, 2018
Second miscarriage associated with low vitamin D – review June 2018 20 Jun, 2018
Pregnancies with more than 40 ng of vitamin D are great - miscarriage, LBW, SGA, preterm – Feb 2018 14 Feb, 2018
Pregnancies with more than 40 ng of vitamin D are great - miscarriage, LBW, SGA, preterm – Feb 2018 14 Feb, 2018
Cesarean (associated with low Vitamin D) increased asthma, obesity, miscarriage and stillbirth – meta-analysis Jan 2018 26 Jan, 2018
Early menarche, miscarriage and stillbirth are associated with heart disease (all are associated with low Vitamin D) – Jan 2018 18 Jan, 2018
Preterm birth far more likely if previous miscarriage and poor Vitamin D receptor – Aug 2017 20 Nov, 2017
APS (associated with miscarriage, stillbirth. preterm delivery and stroke) is 3X more likely if low vitamin D – meta-analysis Oct 2017 13 Oct, 2017
Frequent miscarriage associated with both lower vitamin D and poor Vitamin D receptor – Sept 2017 14 Sep, 2017
Miscarriage in first trimester 2.5X more likely if less than 20 ng of vitamin D – July 2015 07 Jul, 2017
Miscarriage 70 percent more likely if low vitamin D (see also data on CYP27B1) – May 2016 07 Jul, 2017
Just 400 IU of daily Vitamin D reduced miscarriage (recurrent) by 3.5 times – RCT July 2016 07 Jul, 2017
Preterm birth 2X more likely if poor Vitamin D Receptor, 9 X if also had previous miscarriage – June 2017 15 Jun, 2017
Infants have low levels of vitamin D – associations with phototherapy and miscarriage – Dec 2016 01 Jan, 2017
Infants have low vitamin D levels in infants – association with phototherapy and miscarriage – Dec 2016 01 Jan, 2017
Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016 07 Aug, 2016
Abortion 3X higher risk if very low vitamin D – Jan 2016 12 Jun, 2016
Miscarriage 3X more often if very low vitamin D – Jan 2016 12 Jun, 2016
Miscarriage in 2nd trimester associated with low vitamin D – July 2012 07 Sep, 2015

Genetics category listing contains

332 articles in the Genetics category

see also

Vitamin D blood test misses a lot
in Visio for 2023

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family

    especially if it is one of 51+ diseases related to Vitamin D Receptor

+2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase) +3) DNA and VDR tests - 120 to 200 dollars $100 to $250 +4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)

   Genes are good, have enough Magnesium, etc.

+4) Back Pain

   probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc

      • The founder of VitaminDWiki took action with clues #3&4

Vitamin D Receptor category contains

513 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (16 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B		 Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?		Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient		Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Dec 2016 study


BACKGROUND:
Effects of vitamin D deficiency in pregnancy have been associated with some adverse pregnancy outcomes. The 25-hydroxyvitamin D3-1α-hydroxylase (CYP27B1) is integral to the vitamin D metabolic pathway. The enzyme catalyzes localized conversion of pro-hormone 25-hydroxyvitamin D3 to active 1,25-dihydroxyvitamin D3. Our aim was to investigate the expression of CYP27B1 at the fetal-maternal interface in the first trimester pregnancy and to determine whether CYP27B1 was associated with recurrent miscarriage (RM).

METHODS:
Expressions of CYP27B1 mRNA and protein in villi and decidua from 20 women undergoing primary miscarriage, 20 women with RM and 20 women with normal pregnancy were evaluated by western blot, and quantitative real-time PCR. The co-localization of CYP27B1 and certain cytokines including IL-10, IFN-γ, TNF-α, and IL-2 expression were examined using immunohistochemistry and confocal microscopy.

RESULTS:
Women with RM had a significantly lower expression of CYP27B1 mRNA and protein in villous and decidual tissues compared with the normal pregnant women (P = 0.000 in villus, P = 0.002 in decidua for mRNA; P = 0.036 in villus, P = 0.007 in decidua for protein.). Compared with the normal pregnancy, immunostaining for CYP27B1 was significantly decreased in villous trophoblasts and decidual glandular epithelial cells in RM women. No significant differences in the localization of CYP27B1, IL-10, IFN-γ, TNF-α, and IL-2 expression were identified between the normal pregnant and RM women.

CONCLUSIONS:
Women with RM have a lower level of CYP27B1 expression in chorionic villi and decidua compared with normal pregnant women, suggesting that reduced CYP27B1 expression may be associated with RM. The consistent localization of CYP27B1 and IL-10, IFN-γ, TNF-α, and IL-2 expression in villous and decidual tissues suggests the importance of the local production of 1,25(OH)2D3 at the fetal-maternal interface to regulate cytokine responses.
 Download the PDF from VitaminDWiki

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