The synergistic effects of vitamin D and estradiol deficiency on metabolic syndrome in Chinese postmenopausal women.
Menopause. 2019 Jun 10. doi: 10.1097/GME.0000000000001370.
Huang H1,2, Guo J3,2, Chen Q4, Chen X4, Yang Y1, Zhang W5, Liu Y6, Chen X1, Yang D1.
1 Reproductive Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
2 HH and JG equally contributed to this work and should be regarded as co-first authors.
3 Reproductive Medical Center, Beijing Chao Yang Hospital, Capital Medical University, Beijing, China.
4 Health Examination Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
5 Department of Environmental Health Sciences, University at Albany, State University of New York, NY.
6 Pediatric Department, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
- Metabolically Healthy – only 1 in 50 seniors in the US – Nov 2018
- Metabolic Syndrome in Chinese youths 2.5 X more likely if less than 20 ng of vitamin D – Sept 2018
- Half of Women Over 50 Desperately Need This Potent Nutrient (Vitamin D) – April 2018
- Metabolic Syndrome risk increases about 70 percent if poor Vitamin D Receptor
- Metabolic syndrome 1.9 X more likely if senior women had less than 30 ng of Vitamin D – Oct 2017
- Overview Diabetes and vitamin D
- Overview Obesity and Vitamin D
- Estrogen contraception pill doubled the response to 1,000 IU of vitamin D – RCT Sept 2017
- Increasing Estrogen ==> Increases Vitamin D
- Overview Metabolic Syndrome and vitamin D - which has the following
Items in both categories Metabolic Syndrome and Intervention are listed here:
- Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT June 2019
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Metabolic Syndrome risk reduced 44 percent when vitamin D levels increased by 30 nanograms – Aug 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- 5700 IU vitamin D improved various growth factors in overweight people – Oct 2012
Items in both categories Metabolic Syndrome and Women are listed here:
- Metabolic Syndrome 3.5 X more likely if both Vitamin D and Estrogen are low (senior women)– June 2019
- Metabolic Syndrome associated with low vitamin D in abdominal obese women – Jan 2019
- Half of Women Over 50 Desperately Need This Potent Nutrient (Vitamin D) – April 2018
- Metabolic syndrome 1.9 X more likely if senior women had less than 30 ng of Vitamin D – Oct 2017
- Metabolic syndrome 2.4 X more likely if senior women had low vitamin D – Nov 2013
Charts and description at Grassroots Health
OBJECTIVE:
Recent studies show that vitamin D (VitD) deficiency is associated with metabolic syndrome (MetS). Current evidence suggests that estrogen and VitD have similar physiological functions and potentially interact with bone health. We investigated the association between estradiol (E2) and 25-hydroxyvitamin-D 25(OH)D with MetS and its components in Chinese postmenopausal women.
METHODS:
In this cross-sectional study, we examined 616 postmenopausal women (aged 49-86 y) from southern China who were not taking estrogen and VitD/calcium supplements. At the end of data collection, serum E2 and 25(OH)D were measured for each participant. MetS was defined according to the 2006 International Diabetes Federation standard.
RESULTS:
There was a positive correlation between 25(OH)D and E2. Higher 25(OH)D was associated with a favorable lipid profile, blood pressure, and glucose level. E2 was negatively associated with cholesterol, triglycerides, and blood pressure. The odds ratio for MetS was 2.19 (95% CI, 1.19-4.01, P value for trend=0.009) for deficient compared with sufficient women after multivariable adjustment. This association remained unchanged after further adjusting for E2 levels. After stratified analysis by VitD status, low E2 increased MetS risk in women with VitD deficiency (odds ratio = 3.49, 95% CI, 1.45-8.05 for the lowest vs the highest tertile).
CONCLUSIONS:
These results suggest a synergistic role of VitD and E2 deficiency in MetS in Chinese postmenopausal women.