Serum 25-hydroxyvitamin D concentrations and lung cancer risk in never-smoking postmenopausal women.
Cancer Causes Control. 2017 Sep 12. doi: 10.1007/s10552-017-0956-1
Cheng TD1, Song X2, Beresford SAA2, Ho GYF3,4, Johnson KC5, Datta M6, Chlebowski RT7, Wactawski-Wende J8, Qi L9, Neuhouser ML2.
Abstract mentions a trend toward less benefit from Vitamin D if Vitamin A and/or Calcium
- Smoking reduces vitamin D - many studies
- Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017 poor VDR ==> low vitamin D ==> Cancer
- Cancer - Lung category listing has
54 items along with related searches Pages listed in both of the categories Lung Cancer and Vitamin A
- Lung cancer 24 percent less likely if high vitamin D (never-smoking senior women) – Sept 2017
- Lung Cancer reduced by combination of Vitamins D and A – March 2014
- Less Lung Cancer if take more than 800 IU of vitamin D and never smoke or low vitamin A – Oct 2013
- Vitamin A may hinder vitamin D benefits associated with Lung Cancer – July 2013
- Vitamin D protects against lung cancer unless there is excess vitamin A – July 2012
Download the PDF from sci-hub via VitaminDWiki
PURPOSE:
Vitamin D has been implicated in lowering lung cancer risk, but serological data on the association among never-smoking women are limited. We report results examining the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with lung cancer risk among female never smokers. We also examined whether the association was modified by vitamin D supplementation and serum vitamin A concentrations.METHODS:
In the Women's Health Initiative, including the calcium/vitamin D (CaD) Trial, we selected 298 incident cases [191 non-small cell lung cancer (NSCLC) including 170 adenocarcinoma] and 298 matched controls of never smokers. Baseline serum 25(OH)D was assayed by a chemiluminescent method. Logistic regression was used to estimate odds ratios (ORs) for quartiles and predefined clinical cutoffs of serum 25(OH)D concentrations.RESULTS:
Comparing quartiles 4 versus 1 of serum 25(OH)D concentrations, ORs were 1.06 [95% confidence interval (CI) 0.61-1.84] for all lung cancer, 0.94 (95% CI 0.52-1.69) for NSCLC, and 0.91 (95% CI 0.49-1.68) for adenocarcinoma.
Comparing serum 25(OH)D ≥ 75 (high) versus <30 nmol/L (deficient), ORs were 0.76 (95% CI 0.31-1.84) for all lung cancer, 0.71 (95% CI 0.27-1.86) for NSCLC, and 0.81 (95% CI 0.31-2.14) for adenocarcinoma.
There is suggestive evidence that CaD supplementation (1 g calcium + 400 IU D3/day) and a high level of circulating vitamin A may modify the associations of 25(OH)D with lung cancer overall and subtypes (p interaction <0.10).CONCLUSIONS:
In this group of never-smoking postmenopausal women, the results did not support the hypothesis of an association between serum 25(OH)D and lung cancer risk.Printer Friendly Follow this page for updates5979 visitors, last modified 09 Sep, 2021,