Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020

Association of Vitamin D Supplementation With Respiratory Tract Infection in Infants

Matern Child Nutr, e12987 2020 Mar 5, DOI: 10.1111/mcn.12987
Miao Hong 1, Ting Xiong 1, Junmei Huang 1 2, Yuanjue Wu 1, Lixia Lin 1, Zhen Zhang 1, Li Huang 1, Duan Gao 1, Huanzhuo Wang 1, Chun Kang 1, Qin Gao 1, Xuefeng Yang 1, Nianhong Yang 1, Liping Hao 1


Study results when get vitamin D virtually daily

RTILower RTI RTI Hospitalization
Reduced Risk
vs no Vitamin D
1/Reduced Risk 2.2 5.95.5

Chinese take few supplements and have low levels of vitamin D

Infants also get vitamin D weekly, monthly, or via breastmilk if mother is fortifying

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Vitamin D deficiency has been reported to be associated with respiratory tract infection (RTI). However, evidence regarding the effects of vitamin D supplementation on susceptibility of infants to RTI is limited. In this prospective birth cohort study, we examined whether vitamin D supplementation reduced RTI risk in 2,244 infants completing the follow-up from birth to 6 months of age. The outcome endpoint was the first episode of paediatrician-diagnosed RTI or 6 months of age when no RTI event occurred. Infants receiving vitamin D supplements at a daily dose of 400-600 IU from birth to the outcome endpoint were defined as vitamin D supplementation and divided into four groups according to the average frequency of supplementation: 0, 1-2, 3-4, and 5-7 days/week. We evaluated the relationship between vitamin D supplementation and time to the first episode of RTI with Kaplan-Meier plots. The associations of vitamin D supplementation with infant RTI, Lower RTI (LRTI), and RTI-related hospitalization were assessed using modified Poisson regression. The median time to first RTI episode was 60 days after birth (95% CI [60, 90]) for infants without supplementation and longer than 6 months of age for infants with supplementation (p < .001).

We observed inverse trends between supplementation frequency and risk of RTI, LRTI, and RTI-related hospitalization (p for trend < .001), with the risk ratios in the 5-7 days/week supplementation group of 0.46 (95% CI [0.41, 0.50]), 0.17 (95% CI [0.13, 0.24]), and 0.18 (95% CI [0.12, 0.27]), respectively. These associations were significant and consistent in a subgroup analysis stratified by infant feeding.

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