Less Pneumonia in those having more activated vitamin D (kidneys working)– April 2014

Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity

Respiratory Research 2014, 15:53 doi:10.1186/1465-9921-15-53
Mathias W Pletz, Christoph Terkamp, Ulrike Schumacher, Gernot Rohde, Hartwig Schütte, Tobias Welte and Robert Bals

We aimed to explore the association between vitamin D levels and the severity, mortality and microbiological etiology of community-acquired pneumonia.

Vitamin D levels (both, the reservoir form 25-OH and the activated form 1,25-OH2) of 300 randomly selected patients with community-acquired pneumonia due to pre-specified pathogens included in the German competence network (CAPNETZ) study were measured. Prior to statistical analysis, values of 25-OH and 1,25-OH2 were power-transformed to achieve parametric distribution. All further analyses were performed with seasonally and age adjusted values.

There was only a modest (Spearman Coefficient 0.38) positive correlation between 25-OH and 1,25-OH2. For 1,25-OH2 but not 25-OH, the general linear model revealed a significant inverse correlation between serum concentration and CURB score (p = 0.011). Liver and respiratory co-morbidity were associated with significantly lower 25-OH values and renal co-morbidity with significantly lower 1,25-OH2 values. No significant differences of 1,25-OH2 or 25-OH between different pathogens (influenza virus, Legionella spp., Streptococcus pneumoniae) were detected.

For 1,25-OH2, we found a significant and independent (controlled for age, season and pathogen) negative correlation to pneumonia severity. Therefore, supplementation of non-activated vitamin D to protect from pneumonia may be non-sufficient in patients that have a decreased capacity to hydroxylate 25-OH to 1,25-OH2.

From the PDF- which is attached at the bottom of this page

  • “After seasonal adjustment, age had a significant impact on 1,25-OH2 levels (F1,297= 6.06, p = 0.0144) but not on 25-OH levels (F1,297= 0.03, p = 0.8588).”
    VitaminDWiki interpretation: Seniors have kidney problems, thus reducing the activation of vitamin D

Wide variance in the association between activated and typically measure serum level of vitamin D

As much as 50% variation in activated levels between individuals with the same serum level

Interesting: Liver problems reduced serum level, and somewhat reduced the activated level

Kidney problems did, as expected, reduce the activated level without reducing the serum level much


Interesting differences in vitamin D types vs types of Influenza

Influenza type 25-OH 1,25-OH2
Influenza A11 ng64
Influenza B13 ng31

VitaminDWiki speculation: Influenza B degrades the Kidney function.

See also VitaminDWiki

Reductions in Vitamin D is.gd/VitDReductions
Overview Kidney and vitamin D contains the following summary

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