The influence of polymorphisms of fat mass and obesity (FTO, rs9939609) and vitamin D receptor (VDR, BsmI, TaqI, ApaI, FokI) genes on weight loss by diet and exercise interventions in non-diabetic overweight/obese Asian Indians in North India
Eur J Clin Nutr (2020). https://doi.org/10.1038/s41430-020-0560-4
Seema Gulati, Anoop Misra, Rajneesh Tiwari, Meenu Sharma, Ravindra M. Pandey & Ashish Datt Upadhyay
Having a poor Vitamin D receptor is one of the reasons for gaining weight
Items in both categories Obesity and Vitamin D Receptor are listed here:
- Obesity decreases BOTH Vitamin D levels and Vitamin D Receptor activation – Oct 2023
- Risk of sleep apnea in obese increases 3.4X with poor vitamin D Receptor – Sept 2021
- Large weight loss 32X more likely to be achieved if weight gain was due to Vitamin D Receptor – Jan 2020
- Obesity 2X higher risk if a poor Vitamin D Receptor (13th study) – Dec 2019
- Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
- Obesity associated with poor Vitamin D genes (VDR in this study) – Jan 2018
- Skin fold thickness but not BMI associated with poor Vitamin D Receptor in Han Chinese – April 2018
- Resveratrol improves health (Vitamin D receptor, etc.)
- Obesity might be related to Vitamin D genes – July 2018
- Obesity 1.5 X more likely if poor Vitamin D receptor – Dec 2017
- Obesity in 700 young adults associated with a poor Vitamin D Receptor – Jan 2018
- Obese are 30 percent more likely to have poor Vitamin D Receptor – Aug 2017
- Vitamin D restricted in getting to cells by genes, obesity, etc – Jan 2017
- Vitamin D Receptor and Obesity – many studies
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Obesity strongly associated with vitamin D receptor in Saudia Arabia – July 2014
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Objective
The aim of the present study was to evaluate polymorphisms of fat mass and obesity (FTO; rs9939609) and vitamin D receptor (VDR, FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236)] genes on weight loss after lifestyle interventions in Asian Indians.
Methods
In this 6-month pre–post intervention trial, 110 overweight/obese men and women underwent diet and exercise interventions for 180 days resulting in reduction in body weight, (5.1 kg, p < 0.001), waist circumference, and skinfolds.
Results
Association of the following genotypes was seen in those with ≥5% weight loss:
- TT of FTO polymorphism; 35 (81.4%) [OR (95% CI)
- AT, 2.5 (0.6, 10.9); TT, 6.9 (1.6, 28.2); with reference to AA],
- tt of VDR TaqII polymorphism, 12 (92.3%) [OR (95% CI);
- tt, 32.2 (2.4, 436.4); TT, 0.5 (0.08, 3.1); all with reference to Tt],
- bb of VDR BsmI polymorphism; 27 (65.8%) [OR (95% CI)
- Bb, 0.2 (0.04, 0.9); bb,
- 10.6 (0.9, 120.3); all with reference to BB] after adjusting for other genotypes.
Further, analysis of combined influence of genotypes conferring maximum weight loss showed that the following had high odds of ≥5% weight loss:
- (1) TT of FTO gene in combination with BB/Bb of VDR BsmI and
- TT/Tt of VDR TaqI [OR (95% CI) 5.1 (1.5, 17.4)],
- (2) bb of BsmI and AA/AT of FTO and tt of TaqI [OR (95% CI) 3.2 (0.3, 31.7)], and
- (3) bb of BsmI plus TT of FTO and tt of TaqI.
Conclusions
The above observations suggest a significant and independent role of the genotypes of FTO and VDR in influencing weight loss after lifestyle intervention in Asian Indians.