Vitamin D3 supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women. (1-2)
Br J Nutr. 2019 Mar 1:1-31. doi: 10.1017/S0007114519000412
Salma F Ahmad Fuzi1 2, Sohail Mushtaq1
- From the Faculty of Medicine, Dentistry and Life Sciences, University of Chester, Parkgate Road, Chester, UK, CHI 4BJ
- From the Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
- Address correspondence to Associate Professor Sohail Mushtaq, Faculty of Medicine, Dentistry and Life Sciences, University of Chester, Parkgate Road, Chester, UK, CHI 4BJ. Tel: +44 (0)124 4513367, Fax: +44 (0)124511310, Email address: s.mushtaq@chester.ac.uk
Iron added to cereal for 27 year-old women
Half of them got 1500 IU Vitamin D daily, but for only 8 weeks
Expect far better results if dose and duration had been increased
for example:3,000 IU for 15 weeks
See also VitaminDwiki
- Iron and Vitamin D deficiencies are synergistic - April 2015
- Overview Iron Supplements and Vitamin D
- Vitamin D deficiency 2.5 X more likely in iron-deficient children – Dec 2018
- Autistic children have lower levels of Iron, Vitamin D, Magnesium, etc – Oct 2017
- Breastfed infants 6 times more likely to deficient in Vitamin D and Iron – Aug 2015
Items in both categories Iron and Women are listed here:
- Iron increased slightly by small amount of Vitamin D for a short time – RCT Feb 2019
- Iron in blood decreases with vitamin D in males, increases with premenopausal females (Korea)– May 2017
- Low iron in teenage girls is 2X more likely if low vitamin D – 2014
- 2X increased chance of anemia (low iron) associated with low vitamin D – Sept 2013
- Review of Micronutrients such as vitamin D for women and childhood – Aug 2013
- Deficiencies of iron and vitamin D are interrelated in women – March 2013
- Female Athlete health problems may be due to lack of vitamin D and Iron – July 2012
- Why do Saudi postmenopausal women have higher level of vitamin D – Mar 2011
Items in both categories Iron and Pregnancy are listed here:
- Fraternal twin births increasing (twins often associated with low vitamin D) – March 2022
- Anemia 1.6 X more likely during pregnancy if low Vitamin D – meta-analysis Dec 2021
- Pregnancy recommendations – huge differences in Vitamin D, Mg, iron, Iodine, DHA, etc – April 2021
- Micronutrients (such as Vitamin D) needed during pregnancy – May 2016
- Restless legs syndrome 3X more likely during pregnancy (low vitamin D) – Oct 2015
- Anemia in pregnant teens 7X more likely if low vitamin D – April 2015
Download the PDF from Sci-Hub via VitaminDWiki
Accepted manuscript
ABSTRACT
The effect of 38 pg (1500 IU) daily vitamin D3 supplementation, consumed with an iron-fortified
breakfast cereal for 8 weeks, on haematological indicators in iron-deficient female subjects was
investigated. Fifty iron-deficient subjects (plasma ferritin concentration < 20 pg/L; mean age ± SD:
27.4 ± 9.4 years) were randomised to consume an iron-fortified breakfast cereal containing 9 mg of
iron daily, with either a vitamin D3 supplement or placebo. Blood samples were collected at
baseline, interim (4 weeks) and post-intervention (8 weeks) for measurement of iron and vitamin D
status biomarkers. The effect of intervention was analysed using mixed-model repeated measures
ANOVA. Significant increases were observed in two main haematological indices: haemoglobin
concentration and haematocrit level from baseline to post-intervention in the vitamin D group, but
not in the placebo group. The increase from baseline to post-intervention in haemoglobin
concentration in the vitamin D group (135 ± 11 to 138 ± 10 g/L) was significantly higher compared
to the placebo group (131 ± 15 to 128 ± 13 g/L) (P=0.037). The increase in haematocrit level from
baseline to post-intervention was also significantly higher in the vitamin D group (42.0 ± 3.0 to 43.8
± 3.4%) compared to the placebo group (41.2 ± 4.3 to 40.7 ± 3.6%) (P=0.032). Despite the non-
significant changes in plasma ferritin concentration, this study demonstrates that 38 pg
supplemental vitamin D, consumed daily, with iron-fortified breakfast cereal led to improvement in
haemoglobin concentration and haematocrit levels in women with low iron stores. These findings
may have therapeutic implications in the recovery of iron status in iron-deficient populations at a
healthcare level.