The Role of Vitamin D in Immune System and Inflammatory Bowel Disease
Journal of Inflammation Research Volume 2022:15 Pages 3167—3185 https://doi.org/10.2147/JIR.S363840
Wu Z , Liu D, Deng F Zengrong Wu,1,2 Deliang Liu,1,2 Feihong Deng1,2 dfh411@csu.edu.cn
1Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China;
2Research Center of Digestive Disease, Central South University, Changsha, Hunan, 410011, People’s Republic of China
PDF Table of Contents
Chart: Immune system and Vitamin D
Chart Intestines, Vitamin D and immune system
Inflammatory bowel disease (IBD) is a nonspecific inflammatory disease that includes ulcerative colitis (UC) and Crohn’s disease (CD). The pathogenesis of IBD is not fully understood but is most reported associated with immune dysregulation, dysbacteriosis, genetic susceptibility, and environmental risk factors. Vitamin D is an essential nutrient for the human body, and it not only regulates bone metabolism but also the immune system, the intestinal microbiota and barrier. Vitamin D insufficiency is common in IBD patients, and the abnormal low levels of vitamin D are highly correlated with disease activity, treatment response, and risk of relapse of IBD. Accumulating evidence supports the protective role of vitamin D in IBD through regulating the adaptive and innate immunity, maintaining the intestinal barrier and balancing the gut microbiota. This report aims to provide a broad overview of the role vitamin D in the immune system, especially in the pathogenesis and treatment of IBD, and its possible role in predicting relapse.
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VitaminDWiki pages with IBD or IBS in title (25 as of May 2022)
This list is automatically updated
Items found: 43
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IBS - Vitamin D was the only micronutrient under DRV - meta-analysis Oct 2023 |
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16 Dec, 2023 |
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Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – several studies |
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22 Nov, 2023 |
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IBD associated with low vitamin D again (they need to take a gut-friendly form of Vitamin D) – Oct 2023 |
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14 Oct, 2023 |
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IBS reduced by 50,000 IU of Vitamin D (weekly or bi-weekly) – Meta-analysis July 2023 |
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16 Aug, 2023 |
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IBD treated in children by Vitamin D, especially if use more than 2,000 IU daily for 12 weeks – meta-analysis – Sept 2022 |
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14 Sep, 2022 |
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Vitamin D fights IBD, no consensus yet on dose size and type – Aug 2022 |
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26 Aug, 2022 |
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IBS helped by vitamin D (virtually ignoring dose size, type and duration) – meta-analysis June 2022 |
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09 Jul, 2022 |
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IBD is treated by Vitamin D and other Nutraceuticals – June 2022 |
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23 Jun, 2022 |
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IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 |
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30 May, 2022 |
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IBD in children might be associated with low sun exposure |
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28 Feb, 2022 |
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IBD strongly associated with low Vitamin D – Jan 2022 |
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09 Jan, 2022 |
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IBS not helped by daily 3,000 IU Vitamin D (but non-daily and gut-friendly help) – RCT July 2021 |
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31 Jul, 2021 |
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IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 |
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29 Jun, 2021 |
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IBS diarrhea treated by weekly 50,000 IU of Vitamin D – RCT March 2020 |
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25 Mar, 2020 |
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IBD and UV dissertation - 2019 |
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10 Sep, 2019 |
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Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019 |
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17 Jul, 2019 |
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IBD in Finland – 3X increase in 15 years, more prevalent further from equator – Nov 2012 |
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14 May, 2019 |
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Common cold incidence reduced by two thirds (500 IU for IBD with low vitamin D) – RCT Jan 2019 |
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04 Jan, 2019 |
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Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 |
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09 Dec, 2018 |
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IBS (1 in 5 youths) strongly associated with low vitamin D – Dec 2018 |
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01 Dec, 2018 |
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IBD relapse rate reduced by low Vitamin D - meta-analysis Nov 2018 |
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27 Nov, 2018 |
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IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT May 2016 |
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14 Mar, 2018 |
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IBS - many indications that Vitamin D will help - more research needed - March 2018 |
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14 Mar, 2018 |
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IBS – 6 out of 7 studies shows Vitamin D helps, still want more studies – Jan 2018 |
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25 Jan, 2018 |
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Higher Vitamin D increased the benefit of anti-TNF- α drug used for IBD by 2.6 times – Jan 2017 |
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31 Jan, 2017 |
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IBD in Canadian children increasing 7% per year - Nov 2016 |
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22 Nov, 2016 |
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70 percent of people with IBS had symptoms relieved with high dose vitamin D – 2012 |
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04 Nov, 2016 |
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IBD UC and CD at risk of being vitamin D deficient – May 2011 |
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04 Nov, 2016 |
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IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT Dec 2015 |
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25 Aug, 2016 |
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Sleep, Vitamin D, Vitamin B-12, IBS, Fibromyalgia - Gominak March 2015 |
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27 Jul, 2016 |
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IBD deficiencies of Iron and Vitamin D (and new Iron types) – June 2016 |
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20 Jun, 2016 |
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IBS quality of life improved by vitamin D (50,000 IU weekly) – RCT May 2016 |
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17 May, 2016 |
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IBD helped by vitamin D but reluctant to state who helped, in what form, and how much – review Nov 2014 |
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08 Jan, 2016 |
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IBD more likely in areas with low UV ( and thus low vitamin D) – June 2014 |
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05 Dec, 2015 |
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Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis Aug 2015 |
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31 Oct, 2015 |
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IBD (Collitis, Chron’s) was active 6X more often if low vitamin D – June 2015 |
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03 Oct, 2015 |
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Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 |
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17 Feb, 2015 |
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Appears that IBD lowers vitamin D, which increases risk of cancer by 80 percent – Oct 2013 |
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09 Jul, 2014 |
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IBD surgery 5X more likely for non-caucasians with low vitamin D – Oct 2012 |
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03 Nov, 2012 |
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IBD and Crohn but not Colitis associated with low vitamin D – May 2011 |
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05 Jun, 2012 |
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IBD colorectal Cancer and vitamin D – Jan 2011 |
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14 Mar, 2012 |
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Dogs – like humans – with IBD were low on vitamin D – July 2011 |
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14 Mar, 2012 |
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IBD less costly when treated with vitamin D3 compared to D2 – Jan 2012 |
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12 Jan, 2012 |
VitaminDWiki pages with CROHN in (35 as ofMay 2022)
This list is automatically updated
Items found: 39
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Crohn's and Vitamin D - many studies |
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29 Dec, 2022 |
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IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 |
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30 May, 2022 |
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IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 |
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29 Jun, 2021 |
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Crohn’s disease helped when vitamin D level raised above 30 ng – RCT Feb 2015 |
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26 Mar, 2021 |
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Crohn’s Disease reduced for a year by 7 weeks of high dose Vitamin D – RCT March 2021 |
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26 Mar, 2021 |
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Crohn's Disease patients normalizing their Vitamin D levels decreased risk of surgery by 44 percent – Aug 2013 |
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09 Feb, 2021 |
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Crohn's Disease 4X less likely to reoccur after surgery if good level of vitamin D – Feb 2021 |
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09 Feb, 2021 |
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Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020 |
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29 Apr, 2020 |
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Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015 |
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12 Nov, 2019 |
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Crohn’s Disease associated with lower Vitamin D - meta-analysis Sept 2019 |
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28 Sep, 2019 |
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Crohn’s Disease Activity predicted by vitamin D plus 2 additional blood tests – Dec 2018 |
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07 May, 2019 |
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Inflammatory Bowel Disease in children is associated with low Vitamin D, Iron (also low Zinc for Crohn’s) – Aug 2018 |
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28 Aug, 2018 |
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Gut bacteria of Crohn's disease patients improved by Vitamin D – March 2018 |
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15 May, 2018 |
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Crohn's patients with Vitamin D less than 30 ng were 1.8 X more likely to be readmitted within 1 year – April 2017 |
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13 Mar, 2018 |
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Crohn's disease in black children is worse in 6 ways – Dec 2015 |
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10 Dec, 2017 |
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Crohn's Disease flares 20 percent more likely if poor Vitamin D Binding Protein – Oct 2016 |
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09 Nov, 2017 |
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Crohn’s Disease risk increased 3 X if inadequate vitamin D level (another form is needed) – Oct 2017 |
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12 Oct, 2017 |
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Crohn's Disease relapse rate of 3 in 8 with 1,0000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017 |
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16 Jul, 2017 |
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Crohn's Disease relapse rate of 3 in 8 with 1,000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017 |
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15 Jul, 2017 |
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Crohn's disease treated by 2000 IU Vitamin D - RCT June 2015 |
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31 Jan, 2017 |
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Crohn’s disease associated with vitamin D and latitude – meta-analysis Dec 2015 |
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11 Dec, 2016 |
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Boron and Granulomas (TB, Rheumatoid arthritis, Crohn's, Rheumatic Fever etc.) - 2015 |
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14 Nov, 2016 |
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Crohn’s disease associated with low vitamin D, unless in remission (22 vs 28ng)– Dec 2015 |
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30 Jul, 2016 |
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Is vitamin D supplementation a viable treatment for Crohn's disease – Nov 2015 |
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18 Nov, 2015 |
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Infliximab reduction of inflammation (Crohn’s) greatly aided by Vitamin D – Sept 2015 |
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12 Sep, 2015 |
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Crohn's disease treated by Vitamin D - RCT June 2015 |
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07 Aug, 2015 |
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Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 |
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17 Feb, 2015 |
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Crohn’s helped by 5000 IU vitamin D – April 2013 |
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17 Feb, 2015 |
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Crohn’s Disease – strange things such as no change of vitamin D levels with season – Dec 2014 |
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09 Dec, 2014 |
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Surgery for Crohn's disease 2X less likely if managed to raise vitamin D above 30 ng – May 2013 |
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06 May, 2014 |
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Active Crohn's disease is associated with low vitamin D levels – Feb 2013 |
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14 Feb, 2013 |
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About 40 percent more likely to get Crohn’s Disease or UC if have low vitamin D – March 2012 |
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03 Nov, 2012 |
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More than half those with Crohn’s disease have less than 20ng of vitamin D – March 2012 |
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03 Nov, 2012 |
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Even 800 IU vitamin D improved Crohn’s disease bone density – June 2012 |
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03 Jul, 2012 |
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Crohn's disease kids are 2X more likely to have low vitamin D, intervention helps – April 2012 |
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12 Jun, 2012 |
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IBD and Crohn but not Colitis associated with low vitamin D – May 2011 |
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05 Jun, 2012 |
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Crohn’s Disease strongly associated with low vitamin D in South Asians – March 2012 |
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29 Mar, 2012 |
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Extra Vitamin D needed for Crohns |
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14 Mar, 2012 |
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Crohn’s relapse reduced from 29% to 13% by taking 1200 IU of D3 – May 2010 |
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04 Apr, 2011 |
- Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
- Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
- Review in Nov 2013 found that Vitamin D helped
Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
- All items in category gut and vitamin D
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items
Along with gut-friendly information
VitaminDWiki - Gut category contains
| 203 |
items in GUT category - see also Overview Gut and vitamin D,
See also Microbiome category listing has | 33 |
items along with related searches.
VitaminDWiki - Immunity category contains
| 262 |
items in Immunity category
see also
Virus category listing has | 1349 |
items along with related searches
Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
141 VitaminDWiki pages contained "infection" in title (June 2021)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
Only the brain is more complex, nothing about Vitamin D
18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection
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studies are in both Immunity and Virus categories
Note: Gut-Friendly Vitamin D is far better for those with gut problems
Note: A time-release vitamin D would probably be good for gut problems - but do not know of a supplier as of May 2022
VitaminDWiki pages with Colitis in (15 as of May 2022)
This list is automatically updated
Items found: 17
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Ulcerative Colitis and Vitamin D - many studies |
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18 Oct, 2023 |
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Ulcerative Colitis treated 4X better when Vitamin D was added – Meta-Analysis – July 2022 |
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01 Aug, 2022 |
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IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 |
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30 May, 2022 |
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Ulcerative Colitis significantly reduced by 480,000 IU loading dose of nano Vitamin D – RCT July 2019 |
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21 Sep, 2019 |
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Ulcerative Colitis (new) associated with lower free and bioavailable Vitamin D, but not total – Feb 2019 |
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10 May, 2019 |
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Ulcerative Colitis – half have poor level of Vitamin D Receptor vs only one in ten normally – June 2017 |
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01 Apr, 2019 |
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Ulcerative Colitis much worse if low vitamin D – March 2019 |
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23 Mar, 2019 |
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Turmeric stopped Ulcerative Colitis – RCT Feb 2019 |
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03 Mar, 2019 |
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Ulcerative Colitis inflammation treated by weekly vitamin D (40,000 IU) – July 2018 |
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21 Dec, 2018 |
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Colitis treated by activated vitamin D getting into the colon via emulsion (mice) – July 2018 |
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24 Jul, 2018 |
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Ulcerative colitis treated by injection of 300,000 IU of vitamin D – RCT July 2016 |
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29 Apr, 2017 |
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Ulcerative Colitis relapse 25 percent more likely if vitamin D level is lower than 35 ng – June 2016 |
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18 Jan, 2017 |
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Those with Ulcerative colitis and low vitamin D were 3.3X more likely to have anemia – Oct 2013 |
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18 Jan, 2017 |
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Ulcerative colitis associated with both low Vitamin D and poor Vitamin D Receptors – Oct 2016 |
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24 Nov, 2016 |
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IBD and Crohn but not Colitis associated with low vitamin D – May 2011 |
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05 Jun, 2012 |
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Vitamin D as a therapy for colitis: A systematic review – May 2012 |
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05 Jun, 2012 |
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Colitis associated with low level of vitamin D in mice – April 2010 |
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07 Jul, 2010 |
Note: My spouse has very successfully used a nanoemulsion vitamin D to treat her colitis
She had severe attacks of ulcerative colitis many times a year for many decades
Adding oral vitamin D did not appear to help
Previously we had great success applying vitamin D directly to a problem
gums, warts, burns, abrasions, etc.
We evolved ways to get vitamin d directly to this problem
Vitamin D powder added to water helped some when a teaspoon of it was inserted into the rectum
Adding salt to the water helped
100,0000 IU of nanoemulsion also was good
Ended up using 200,000 IU of nanoemulsion vitamin D in 1 pint of water with a "pinch" of - using about a tablespoon at a time
Similar attack frequency, but far less intense.
The problem goes away after 3 nightly applications