IVF 50 percent more likely to result in pregnancy if high vitamin D – meta-analysis Nov 2017

Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-analysis - Nov 2017

Hum Reprod. 2017 Nov 15:1-16. doi: 10.1093/humrep/dex326. [Epub ahead of print]
Chu J1,2, Gallos I1,2, Tobias A1,3, Tan B4,5, Eapen A1,2, Coomarasamy A1,2.

 Download the PDF from VitaminDWiki

!More Live Births if > 30 ng of vitamin D

More Pregnancies if > 30 ng of vitamin D
STUDY QUESTION:Is serum vitamin D associated with live birth rates in women undergoing ART?

SUMMARY ANSWER: Women undergoing ART who are replete in vitamin D have a higher live birth rate than women who are vitamin D deficient or insufficient.

Vitamin D deficiency has been associated with an increased risk of abnormal pregnancy implantation as well as obstetric complications such as pre-eclampsia and fetal growth restriction. However, the effect of vitamin D on conception and early pregnancy outcomes in couples undergoing ART is poorly understood.

A systematic review and meta-analysis of 11 published cohort studies (including 2700 women) investigating the association between vitamin D and ART outcomes.

Literature searches were conducted to retrieve studies which reported on the association between vitamin D and ART outcomes. Databases searched included MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and CINAHL. Eleven studies matched the inclusion criteria.

Live birth was reported in seven of the included studies (including 2026 patients). Live birth was found to be more likely in women replete in vitamin D when compared to women with deficient or insufficient vitamin D status (OR 1.33 [1.08-1.65]). Five studies (including 1700 patients) found that women replete in vitamin D were more likely to achieve a positive pregnancy test than women deficient or insufficient in vitamin D (OR 1.34 ([1.04-1.73]). All 11 of the included studies (including 2700 patients) reported clinical pregnancy as an outcome. Clinical pregnancy was found to be more likely in women replete in vitamin D (OR 1.46 [1.05-2.02]). Six studies (including 1635 patients) reported miscarriage by vitamin D concentrations. There was no association found between miscarriage and vitamin D concentrations (OR 1.12 [0.81-1.54]. The included studies scored well on the Newcastle-Ottawa quality assessment scale.

Although strict inclusion criteria were used in the conduct of the systematic review, the included studies are heterogeneous in population characteristics and fertility treatment protocols.

The findings of this systematic review show that there is an association between vitamin D status and reproductive treatment outcomes achieved in women undergoing ART. Our results show that vitamin D deficiency and insufficiency could be important conditions to treat in women considering ARTs. A randomized controlled trial to investigate the benefits of vitamin D deficiency treatment should be considered to test this hypothesis.

PMID: 29149263 DOI: 10.1093/humrep/dex326

Live birth 26% more likely after IVF if good level of vitamin D - Meta-analysis Feb 2018

Reprod Biol Endocrinol. 2018 Feb 9;16(1):13. doi: 10.1186/s12958-018-0324-3.
Whether vitamin D was associated with clinical outcome after IVF/ICSI: a systematic review and meta-analysis.
Zhao J1, Huang X1, Xu B1, Yan Y1, Zhang Q1, Li Y2.

There exist contradictive views on whether the vitamin D has association with clinical outcome of in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI). The present meta-analysis aim to establish whether vitamin D was associated with clinical outcomes of IVF/ICSI.

MEDLINE, Google Scholar and the Cochrane Library from database inception to March 2017 were searched. Clinical studies, which evaluated the association of vitamin D level and the clinical outcomes after IVF/ICSI, were included. The Main Outcome Measures were clinical pregnancy, ongoing pregnancy, and live birth.

In the analysis of clinical pregnancy, 9 cohort studies were included. Of which, 2 studies and 3 studies were identified in analyzing ongoing pregnancy and live birth, respectively. Meta-analysis showed trends toward lower clinical pregnancy [RR 0.91, (95% CI 0.77-1.07)] and higher ongoing pregnancy [RR 1.06, (95% CI 0.95-1.19)] for women with deficient level of vitamin D. The probability of live birth for women with deficient level of vitamin D was significantly lower than cases with sufficient level of vitamin D [RR 0.74, (95% CI 0.58-0.90)].

CONCLUSIONS: Deficient vitamin D was associated with decreased probability of live birth after IVF/ICSI. So vitamin D should be supplied to women with deficient level vitamin D.

PMID: 29426322 DOI: 10.1186/s12958-018-0324-3

 Download the PDF from VitaminDWiki

4192 visitors, last modified 27 Sep, 2019,
Printer Friendly Follow this page for updates