IBS diarrhea treated by weekly 50,000 IU of Vitamin D – RCT March 2020

Vitamin D3 Supplementation in Diarrhea-Predominant Irritable Bowel Syndrome Patients: The Effects on Symptoms Improvement, Serum Corticotropin-Releasing Hormone, and Interleukin-6 - A Randomized Clinical Trial

Complement Med Res, 1-8 2020 Mar 23, DOI: 10.1159/000506149
Masoumeh Khalighi Sikaroudi 1, Marjan Mokhtare 1, Leila Janani 2, Amir Hossein Faghihi Kashani 1, Mohsen Masoodi 1, Shahram Agah 1, Narjes Abbaspour 3, Afsaneh Dehnad 4, Farzad Shidfar 5

VitaminDWiki

Study would probably have done even better if they had used a gut-friendly form of vitamin D

Overview Gut and vitamin D has the following summary

Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
Review in Nov 2013 found that Vitamin D helped
Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
All items in category gut and vitamin D 203 items

Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart

Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio	Form	Speed	Duration
10	Injection ($$$) or Calcidiol or Calcitriol	D - Slow C -Fast	Long
10	Sun/UVB	Slow	Long
10	Topical (skin patch/cream, vagina)	Slow Fast nano	Normal
9	Nanoemulsion -mucosal perhaps activates VDR	Fast	Normal
9?	Inhaled (future)	Fast	Normal
8	Bio-D-Mulsion Forte	Normal	Normal
6	Water soluble (Bio-Tech)	Normal	Normal
4	Sublingual/spray (some goes into gut)	Fast	Normal
3	Coconut oil based	Slow	Normal
2	Food (salmon etc.)	Slow	Normal
2	Olive oil based (majority)	Slow	Normal

Bio Form Speed Duration
10 Injection ($$$)
or Calcidiol or Calcitriol D - Slow
C -Fast Long
10 Sun/UVB Slow Long
10 Topical
(skin patch/cream, vagina) Slow
Fast nano Normal
9 Nanoemulsion -mucosal
perhaps activates VDR Fast Normal
9? Inhaled (future) Fast Normal
8 Bio-D-Mulsion Forte Normal Normal
6 Water soluble (Bio-Tech) Normal Normal
4 Sublingual/spray
(some goes into gut) Fast Normal
3 Coconut oil based Slow Normal
2 Food (salmon etc.) Slow Normal
2 Olive oil based (majority) Slow Normal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

Gut category listing contains the following

203 items in GUT category - see also Overview Gut and vitamin D,

Ulcerative Colitis and Vitamin D - many studies 12+
"celiac disease" OR CD 1830 items July 2019
IBS or IBD or IRRITABLE BOWEL in title of 41 VitaminDWiki pages as of Aug 2022
Gut-Friendly forms of vitamin D
- such as: bio-emulsion, topical, spray, sublingual, inhaled, injection .

See also Microbiome category listing has 33 items along with related searches.

Items in both categories Gut and Intervention - non daily are listed here:

VitaminDWiki pages containing IBS or IBD or IRRITABLE BOWEL in title

Items found: 47

Title		Modified
IBS - Vitamin D was the only micronutrient under DRV - meta-analysis Oct 2023		16 Dec, 2023
Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – several studies		22 Nov, 2023
IBD associated with low vitamin D again (they need to take a gut-friendly form of Vitamin D) – Oct 2023		14 Oct, 2023
IBS reduced by 50,000 IU of Vitamin D (weekly or bi-weekly) – Meta-analysis July 2023		16 Aug, 2023
Irritable Bowel Syndrome and Vitamin D - many studies		30 Jun, 2023
IBD treated in children by Vitamin D, especially if use more than 2,000 IU daily for 12 weeks – meta-analysis – Sept 2022		14 Sep, 2022
Vitamin D fights IBD, no consensus yet on dose size and type – Aug 2022		26 Aug, 2022
IBS helped by vitamin D (virtually ignoring dose size, type and duration) – meta-analysis June 2022		09 Jul, 2022
IBD is treated by Vitamin D and other Nutraceuticals – June 2022		23 Jun, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015		30 May, 2022
IBD in children might be associated with low sun exposure		28 Feb, 2022
IBD strongly associated with low Vitamin D – Jan 2022		09 Jan, 2022
IBS not helped by daily 3,000 IU Vitamin D (but non-daily and gut-friendly help) – RCT July 2021		31 Jul, 2021
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021		29 Jun, 2021
IBS diarrhea treated by weekly 50,000 IU of Vitamin D – RCT March 2020		25 Mar, 2020
Irritable Bowel Syndrome treated by weekly 50,000 IU Vitamin D – RCT Feb 2019		18 Jan, 2020
IBD and UV dissertation - 2019		10 Sep, 2019
Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019		17 Jul, 2019
IBD in Finland – 3X increase in 15 years, more prevalent further from equator – Nov 2012		14 May, 2019
Common cold incidence reduced by two thirds (500 IU for IBD with low vitamin D) – RCT Jan 2019		04 Jan, 2019
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018		09 Dec, 2018
IBS (1 in 5 youths) strongly associated with low vitamin D – Dec 2018		01 Dec, 2018
IBD relapse rate reduced by low Vitamin D - meta-analysis Nov 2018		27 Nov, 2018
IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT May 2016		14 Mar, 2018
IBS - many indications that Vitamin D will help - more research needed - March 2018		14 Mar, 2018
Irritable Bowel Syndrome: social media indicates that vitamin D is a good treatment – Oct 2013		05 Feb, 2018
IBS – 6 out of 7 studies shows Vitamin D helps, still want more studies – Jan 2018		25 Jan, 2018
Higher Vitamin D increased the benefit of anti-TNF- α drug used for IBD by 2.6 times – Jan 2017		31 Jan, 2017
IBD in Canadian children increasing 7% per year - Nov 2016		22 Nov, 2016
70 percent of people with IBS had symptoms relieved with high dose vitamin D – 2012		04 Nov, 2016
IBD UC and CD at risk of being vitamin D deficient – May 2011		04 Nov, 2016
IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT Dec 2015		25 Aug, 2016
Sleep, Vitamin D, Vitamin B-12, IBS, Fibromyalgia - Gominak March 2015		27 Jul, 2016
IBD deficiencies of Iron and Vitamin D (and new Iron types) – June 2016		20 Jun, 2016
IBS quality of life improved by vitamin D (50,000 IU weekly) – RCT May 2016		17 May, 2016
IBD helped by vitamin D but reluctant to state who helped, in what form, and how much – review Nov 2014		08 Jan, 2016
IBD more likely in areas with low UV ( and thus low vitamin D) – June 2014		05 Dec, 2015
Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis Aug 2015		31 Oct, 2015
IBD (Collitis, Chron’s) was active 6X more often if low vitamin D – June 2015		03 Oct, 2015
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011		17 Feb, 2015
Appears that IBD lowers vitamin D, which increases risk of cancer by 80 percent – Oct 2013		09 Jul, 2014
Irritable Bowel Syndrome - can it be treated by 3000 IU of vitamin D - RCT Feb 2014		28 Feb, 2014
IBD surgery 5X more likely for non-caucasians with low vitamin D – Oct 2012		03 Nov, 2012
IBD and Crohn but not Colitis associated with low vitamin D – May 2011		05 Jun, 2012
IBD colorectal Cancer and vitamin D – Jan 2011		14 Mar, 2012
Dogs – like humans – with IBD were low on vitamin D – July 2011		14 Mar, 2012
IBD less costly when treated with vitamin D3 compared to D2 – Jan 2012		12 Jan, 2012

Objectives: This study aimed to evaluate whether vitamin D deficiency is associated with the severity of symptoms of irritable bowel syndrome (IBS) patients. Stress and gut inflammation can increase the serum level of corticotropin-releasing hormone (CRH) and interleukin-6 (IL-6), leading to a change in bowel movements. The aim of this study was to evaluate the anti-inflammatory and psychological effects of vitamin D3 supplementation on the symptom improvement of patients with a diarrhea-predominant form of IBS (IBS-D).

Methods: Eighty-eight IBS-D patients (age: 18-65 years) based on Rome IV criteria who suffered from vitamin D deficiency and/or insufficiency were enrolled in this randomized, placebo-controlled trial from February 2017 to May 2018 at Rasoul-e-Akram Hospital, Tehran, Iran. Participants were randomly divided into two groups. The intervention group received 50,000 IU vitamin D3 weekly and the control group received a placebo for 9 weeks. All patients received Mebeverine 135 mg twice a day besides supplementation. The IBS Severity Score System (IBS-SSS), serum 25(OH) vitamin D3, CRH, and IL-6 were measured before and after interventions.

Results: Seventy-four patients completed the study. The severity of IBS symptoms (p < 0.01) and IL-6 (p = 0.02) decreased significantly in the intervention group as compared to the control group, but there was no significant difference in the serum level of CRH. Also, in the treatment group, IBS-SSS and IL-6 were significantly reduced at the end of the study from baseline (p < 0.01 and p < 0.03, respectively).

Conclusion: Our findings indicate that vitamin D3 supplementation can modulate the serum level of CRH and IL-6 and can improve symptoms in IBS-D patients. Vitamin D3 supplementation should be considered in IBS-D patients who suffer from vitamin D deficiency and/or insufficiency.