IBD treated in children by Vitamin D, especially if use more than 2,000 IU daily for 12 weeks – meta-analysis – Sept 2022

Vitamin D therapy in pediatric patients with inflammatory bowel disease: a systematic review and meta-analysis

World J Pediatr. 2022 Sep 13. doi: 10.1007/s12519-022-00605-6   PDF can be viewed in Deepdyve
Mohammad Hassan Sohouli 1 2 , Fatemeh Farahmand 1 , Hosein Alimadadi 1 , Parisa Rahmani 1 , Farzaneh Motamed 1 , Elma Izze da Silva Magalhães 3 , Pejman Rohani 4 5

Background: There is some evidence for the role of vitamin D deficiency in the pathogenesis of inflammatory bowel disease (IBD) in the pediatric population. However, the results are contradictory. Therefore, we have conducted a systematic review and meta-analysis to evaluated the effect of vitamin D on pediatric patients with IBD.

Methods: We carried out a systematic search in databases from inception until 20 January 2022. We included all relevant articles that evaluate the efficacy and safety of vitamin D on disease activity, inflammatory factors, and vitamin D and calcium levels in pediatric patients with IBD. Random effects models were used to combine the data. The main outcomes were then analyzed using weight mean difference (WMD) and respective 95% confidence interval (CI).

Results: Fifteen treatment arms met the eligibility criteria and were included. Pooled estimates indicated that intervention with vitamin D has a significantly beneficial effect on 25-hydroxyvitamin D3 [25(OH) D3] (pooled WMD of 17.662 ng/mL; CI 9.77-25.46; P < 0.001), calcium (pooled WMD of 0.17 mg/dL; CI 0.04-0.30; P = 0.009), and inflammatory factors including C-reactive protein (CRP) (pooled WMD of -6.57 mg/L; CI -11.47 to -1.67; P = 0.009) and erythrocyte sedimentation rate (ESR) (pooled WMD of -7.94 mm/h; CI -12.65 to -3.22; P = 0.001) levels. In addition, this effect was greater for vitamin D levels at doses greater than 2000 IU, and when follow-up duration was more than 12 weeks.

Conclusion: This study showed that vitamin D therapy can have a significant and beneficial effect on 25(OH) D3, calcium, and inflammatory factors in children and adolescents with IBD.

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3+ in infant-Child VitaminDWiki pages with IBD in the title

This list is automatically updated

Items found: 3

51+ VitaminDWiki pages with IBD in the title

This list is automatically updated

Items found: 53
Title Modified
Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – several studies 22 Nov, 2023
IBD associated with low vitamin D again (they need to take a gut-friendly form of Vitamin D) – Oct 2023 14 Oct, 2023
IBD treated in children by Vitamin D, especially if use more than 2,000 IU daily for 12 weeks – meta-analysis – Sept 2022 14 Sep, 2022
Vitamin D fights IBD, no consensus yet on dose size and type – Aug 2022 26 Aug, 2022
IBD is treated by Vitamin D and other Nutraceuticals – June 2022 23 Jun, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
Immune system and vitamin D, with emphasis on Inflammatory Bowel Disease – May 2022 29 May, 2022
IBD in children might be associated with low sun exposure 28 Feb, 2022
IBD strongly associated with low Vitamin D – Jan 2022 09 Jan, 2022
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 29 Jun, 2021
Inflammatory Bowel Disease 1.5 X more likely if low vitamin D – meta-analysis Dec 2019 26 Nov, 2019
Vitamin D added to margarine reduced inflammatory bowel disease by 13 percent 30 years later – Nov 2019 14 Nov, 2019
Inflammatory Bowel Disease – proposed Vitamin D protocol – Oct 2019 29 Oct, 2019
Inflammatory Bowel Disease Inflammation and Vitamin D – scores of studies and trials – Aug 2019 16 Sep, 2019
IBD and UV dissertation - 2019 10 Sep, 2019
Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019 17 Jul, 2019
Inflammatory bowel disease, gut bionome and Vitamin D Receptor – 2018 13 Jun, 2019
IBD in Finland – 3X increase in 15 years, more prevalent further from equator – Nov 2012 14 May, 2019
Resveratrol and inflammatory bowel disease: the evidence so far – June 2018 28 Apr, 2019
Inflammatory bowel diseases are associated with Vitamin D etc. – meta-meta-analysis - April 2019 25 Apr, 2019
The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease – March 2019 20 Mar, 2019
Common cold incidence reduced by two thirds (500 IU for IBD with low vitamin D) – RCT Jan 2019 04 Jan, 2019
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 09 Dec, 2018
IBD relapse rate reduced by low Vitamin D - meta-analysis Nov 2018 27 Nov, 2018
Inflammatory Bowel Disease in children is associated with low Vitamin D, Iron (also low Zinc for Crohn’s) – Aug 2018 28 Aug, 2018
Inflammatory Bowel Disease associated with low Vitamin D, low Zinc, and low Selenium – May 2017 08 Mar, 2018
Inflammatory Bowel Disease and Vitamin D review (needs 40-50 ng) – Feb 2018 26 Feb, 2018
Inflammatory Bowel Disease associated with many more problems if low vitamin D – May 2017 09 Jun, 2017
Inflammatory Bowel Disease treated by both Vitamin D and Vitamin A – Dec 2016 25 Apr, 2017
Higher Vitamin D increased the benefit of anti-TNF- α drug used for IBD by 2.6 times – Jan 2017 31 Jan, 2017
IBD in Canadian children increasing 7% per year - Nov 2016 22 Nov, 2016
IBD UC and CD at risk of being vitamin D deficient – May 2011 04 Nov, 2016
Inflammatory bowel disease, Vitamin D, and immunity – Oct 2016 28 Oct, 2016
Vitamin D and Inflammatory Bowel Disease – review April 2015 18 Aug, 2016
IBD deficiencies of Iron and Vitamin D (and new Iron types) – June 2016 20 Jun, 2016
IBD helped by vitamin D but reluctant to state who helped, in what form, and how much – review Nov 2014 08 Jan, 2016
IBD more likely in areas with low UV ( and thus low vitamin D) – June 2014 05 Dec, 2015
Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis Aug 2015 31 Oct, 2015
IBD (Collitis, Chron’s) was active 6X more often if low vitamin D – June 2015 03 Oct, 2015
Inflammatory Bowel Disease and Vitamin D – review May 2015 27 May, 2015
Better response to Inflammatory Bowel Disease drug if more than 30 ng of vitamin D – March 2014 18 Apr, 2015
Inflammatory bowel disease – Vitamin D looks promising – Feb 2015 25 Mar, 2015
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 17 Feb, 2015
Inflammatory bowel diseases treated with vitamin D – Review May 2014 13 Dec, 2014
Inflammatory bowel diseases are helped by vitamin D – commissioned review Nov 2013 10 Aug, 2014
Appears that IBD lowers vitamin D, which increases risk of cancer by 80 percent – Oct 2013 09 Jul, 2014
Inflammatory Bowel Disease and Lymphoma – associated with low vitamin D in cats too – Jan 2014 19 Jan, 2014
Inflammatory bowel disease and vitamin D – review Aug 2012 18 Nov, 2013
IBD surgery 5X more likely for non-caucasians with low vitamin D – Oct 2012 03 Nov, 2012
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
IBD colorectal Cancer and vitamin D – Jan 2011 14 Mar, 2012
Dogs – like humans – with IBD were low on vitamin D – July 2011 14 Mar, 2012
IBD less costly when treated with vitamin D3 compared to D2 – Jan 2012 12 Jan, 2012

VitaminDWiki - Overview Gut and vitamin D contains

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 205 items

VitaminDWiki - Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
Image

Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
   you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol		D - Slow
C -Fast		Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)		Slow
Fast nano		Normal
9Nanoemulsion -mucosal
perhaps activates VDR		FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)		FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

See also VitaminDWiki

This list is automatically updated

Items found: 52
Title Modified
IBS - Vitamin D was the only micronutrient under DRV - meta-analysis Oct 2023 16 Dec, 2023
IBS reduced by 50,000 IU of Vitamin D (weekly or bi-weekly) – Meta-analysis July 2023 16 Aug, 2023
Crohn's and Vitamin D - many studies 29 Dec, 2022
IBS helped by vitamin D (virtually ignoring dose size, type and duration) – meta-analysis June 2022 09 Jul, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
IBS not helped by daily 3,000 IU Vitamin D (but non-daily and gut-friendly help) – RCT July 2021 31 Jul, 2021
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 29 Jun, 2021
Crohn’s disease helped when vitamin D level raised above 30 ng – RCT Feb 2015 26 Mar, 2021
Crohn’s Disease reduced for a year by 7 weeks of high dose Vitamin D – RCT March 2021 26 Mar, 2021
Crohn's Disease patients normalizing their Vitamin D levels decreased risk of surgery by 44 percent – Aug 2013 09 Feb, 2021
Crohn's Disease 4X less likely to reoccur after surgery if good level of vitamin D – Feb 2021 09 Feb, 2021
Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020 29 Apr, 2020
IBS diarrhea treated by weekly 50,000 IU of Vitamin D – RCT March 2020 25 Mar, 2020
Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015 12 Nov, 2019
Crohn’s Disease associated with lower Vitamin D - meta-analysis Sept 2019 28 Sep, 2019
Crohn’s Disease Activity predicted by vitamin D plus 2 additional blood tests – Dec 2018 07 May, 2019
IBS (1 in 5 youths) strongly associated with low vitamin D – Dec 2018 01 Dec, 2018
Inflammatory Bowel Disease in children is associated with low Vitamin D, Iron (also low Zinc for Crohn’s) – Aug 2018 28 Aug, 2018
Gut bacteria of Crohn's disease patients improved by Vitamin D – March 2018 15 May, 2018
IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT May 2016 14 Mar, 2018
IBS - many indications that Vitamin D will help - more research needed - March 2018 14 Mar, 2018
Crohn's patients with Vitamin D less than 30 ng were 1.8 X more likely to be readmitted within 1 year – April 2017 13 Mar, 2018
IBS – 6 out of 7 studies shows Vitamin D helps, still want more studies – Jan 2018 25 Jan, 2018
Crohn's disease in black children is worse in 6 ways – Dec 2015 10 Dec, 2017
Crohn's Disease flares 20 percent more likely if poor Vitamin D Binding Protein – Oct 2016 09 Nov, 2017
Crohn’s Disease risk increased 3 X if inadequate vitamin D level (another form is needed) – Oct 2017 12 Oct, 2017
Crohn's Disease relapse rate of 3 in 8 with 1,0000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017 16 Jul, 2017
Crohn's Disease relapse rate of 3 in 8 with 1,000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017 15 Jul, 2017
Crohn's disease treated by 2000 IU Vitamin D - RCT June 2015 31 Jan, 2017
Crohn’s disease associated with vitamin D and latitude – meta-analysis Dec 2015 11 Dec, 2016
Boron and Granulomas (TB, Rheumatoid arthritis, Crohn's, Rheumatic Fever etc.) - 2015 14 Nov, 2016
70 percent of people with IBS had symptoms relieved with high dose vitamin D – 2012 04 Nov, 2016
IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT Dec 2015 25 Aug, 2016
Crohn’s disease associated with low vitamin D, unless in remission (22 vs 28ng)– Dec 2015 30 Jul, 2016
Sleep, Vitamin D, Vitamin B-12, IBS, Fibromyalgia - Gominak March 2015 27 Jul, 2016
IBS quality of life improved by vitamin D (50,000 IU weekly) – RCT May 2016 17 May, 2016
Is vitamin D supplementation a viable treatment for Crohn's disease – Nov 2015 18 Nov, 2015
Infliximab reduction of inflammation (Crohn’s) greatly aided by Vitamin D – Sept 2015 12 Sep, 2015
Crohn's disease treated by Vitamin D - RCT June 2015 07 Aug, 2015
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 17 Feb, 2015
Crohn’s helped by 5000 IU vitamin D – April 2013 17 Feb, 2015
Crohn’s Disease – strange things such as no change of vitamin D levels with season – Dec 2014 09 Dec, 2014
Surgery for Crohn's disease 2X less likely if managed to raise vitamin D above 30 ng – May 2013 06 May, 2014
Active Crohn's disease is associated with low vitamin D levels – Feb 2013 14 Feb, 2013
About 40 percent more likely to get Crohn’s Disease or UC if have low vitamin D – March 2012 03 Nov, 2012
More than half those with Crohn’s disease have less than 20ng of vitamin D – March 2012 03 Nov, 2012
Even 800 IU vitamin D improved Crohn’s disease bone density – June 2012 03 Jul, 2012
Crohn's disease kids are 2X more likely to have low vitamin D, intervention helps – April 2012 12 Jun, 2012
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
Crohn’s Disease strongly associated with low vitamin D in South Asians – March 2012 29 Mar, 2012
Extra Vitamin D needed for Crohns 14 Mar, 2012
Crohn’s relapse reduced from 29% to 13% by taking 1200 IU of D3 – May 2010 04 Apr, 2011
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