Great article by Bill Sardi Why Reyes-syndrome prevailed then suddenly disappeared
There was a big scare of aspirin use by children in the 1980's
People switched to using Tylenol (a liver toxin)
It appears that aspirin decreased vitamin C, which caused the Reyes problem for children
The problem went away when everyone started taking Vitamin C - due to Linus Pauling
It appears that Reyes Syndrome is also related to vitamin D deficiency
The following graph from NEJM 1999 shows the strong relationship between Reyes Syndrome and season for those with dark skins