New hypotheses on sunlight and the geographic variability of multiple sclerosis prevalence.
Neurol Sci. 2010 Feb 26.
Department of Neurology, Jacobs Neurological Institute, State University of New York-Buffalo, 100 High Street, Buffalo, NY 14203, United States.
Multiple sclerosis is an autoimmune demyelinating disorder of the central nervous system. Its etiology continues to be elucidated. The debate about the environmental impact on the disease etiology and progression has focused on sun light exposure in the recent past, but mainly as it applies to vitamin D and its derivatives.
This paper will discuss how sunlight stimulus may effect neuronal and microglial antigenic presentation based on sunlight-dependent neuronal activity, as well as how sunlight may alter the amount of vitamin A and melatonin levels during immune development in the central nervous system.
Changes in the number of antigens presented to lymphocytes by antigen-presenting cells for self-selective removal during immune development could therefore alter the number of circulating self-recognizing B and T-lymphocytes. This situation would increase susceptibility to a significantly greater number of self-antigens, and lead to autoimmune disorders such as multiple sclerosis. Copyright © 2010 Elsevier B.V. All rights reserved. PMID: 20189603
See also VitaminDWiki
Items in both categories MS and UV are listed here:
- Mutiple Sclerosis half as likely in children spending 30 to 60 minutes per day in the sun – Dec 2021
- Sun reduces risk of Multiple Sclerosis via both Vitamin D and another way – Dec 2019
- UV helped EAE mice (MS) designed to not respond to Vitamin D – Oct 2019
- Multiple Sclerosis 2X more likely if low winter UV – June 2018
- Multiple Sclerosis half as likely if get plenty of sunshine (not a news item) – March 2018
- Clinically Isolated Syndrome progresses to Multiple Sclerosis, unless UVB treatments – RCT Dec 2017
- Vitamin D and Sun conference – Germany June 2017
- Multiple Sclerosis suppressed by an Ultraviolet wavelength not associated with Vitamin D (mice) – Nov 2016
- Multiple Sclerosis helped by UV – possibly via cytokines, etc. – Oct 2015
- Hypothesis – Multiple Sclerosis risk increases with low UV, viral infections, and antibiotics in childhood – March 2015
- How UVB reduces autoimmune diseases such as Multiple Sclerosis – April 2014
- UV decreases Multiple Sclerosis via cis-urocanic acid (and via vitamin D) – June 2013
- MS prevention by UV is 2X better than prevention by vitamin D levels – Jan 2012
- There is more in UV than vitamin D which suppresses MS in mice – April 2010
- UV produces more than vitamin D – Aug 2011
- Lack of UV 20X more associated with MS than any other variable – Dec 2010
- Hypothesis - more in sunshine than vitamin D to reduce MS – Feb 2010
- MS UV and Vitamin D – 2009
- Lack of UV increased offspring MS - April 2010
- Mouse MS: UVB but not Vitamin D reduced incidence - April 2010