How often might 50,000 IU vitamin D be taken - results of clinical trials

There have been many extremely successful vitamin D intervention trials.
Often the trials are random-controlled and double-blind: neither the doctor nor the subject knows who gets it
The trials are listed in the following table are sorted by the number of days between doses of 50,000 IU.
It appears that the higher the dose of vitamin D the more diseases which are prevented or treated.

50,000 IU
Health ProblemPrevent
Reduction in
symptoms or
number of people
with symptoms
RCT = Random Controlled Trial
CT = Clinical Trial
Proof #*
2Traumatic Brain Injury T 2X RCT, 20,000 IU24
2Raynaud's SyndromeT 40 % RCT, visual scale10
2Multiple SclerosisR 95% Recovered CT, 20K-140,K IU/day +Vit B2 43
3Sickle Cell T Less painRCT up to 100,000 IU/week22
4Sleep disorder RRecoveredCT, 60-80 ng +Vit B12
5Muscle fatigue T ReducedCT, 20,000 IU every 2nd day
5Back Pain T 95% reducedCT, 5,000-10,000/day
5Cluster Headaches R80% curedCT, 10,000/day+ Omega-3 etc.
5Parkinson's DiseaseT Ongoing Trial RCT, 50,000 IU/week
7Leg ulcer healingT 4X fasterRCT, 50,000 IU/week small study23
7Menstrual painP 76 %RCT, 7000 IU avg11
7Skin problems resolvedT 70 % RCT, 50,000 IU/week
7 FibromyalgiaT Significantly reduced RCT, 50,000 IU/week
7Multiple SclerosisP 68%RCT, 7100 IU prevent pre-MS ==> MS26
7Chronic Obstructive Pulmonary DiseaseT 17X improvement CT (not random), 50,000 IU/week45
9 Chronic kidney disease T 50 % not need dialysisRCT, 40,000 IU / week
9Gestational DiabetesP 40% RCT, 5,000 IU44
9Low vitamin D while breastfed P All > 20 ngRCT, 5,000 IU38
10 PAINT not yet published Clinical Trial, 34,590 IU/week
12Diabetes T2T 62 % RCT, CRP reduction, 4000 IU 4
12Pregnancy risks P 50 % RCT, 4000 IU12
12C-section, unplannedP 50 % RCT, 4000 IU, small study13
12Respiratory Tract InfectionP 63 %RCT 4000 IU 1 year20
12Prostate Cancer T Fewer +coresRCT, 4000 IU (2012)35
12Hives, Chronic T Reduced 40% RCT, 4000 IU added 40
12Muscle in seniorsT +17 %RCT, 4000 IU30
14Fibrolyalgia T Reduced RCT, 30-48 ng39
15LupusT No flaresLoad then 100,000/month21
Note: due to short half life, should not take 50,000 IU any less frequently than about 18 days
21HypertensionT 149 to 142 RCT, mm Hg avg., 2400 IU1
25Influenza P 90 % RCT, 2000 IU6
25GingivitisT 88 %RCT, 2000 IU29
25Antibiotic use when >70yT 47 %RCT, 60,000 IU/month31
25Weight LossT Reduced extra 5 lbs RCT, 2000 IU +diet +exercise 42
30Asthma T ReducedRCT, 60,000 IU/month36
45Parkinson's DiseaseT StabilizeRCT, 1200 IU25
45Breast Cancer P 60 % RCT 1100 IU16
50 Cardiovascular T 32 % fewer deaths
after heart failure
CT, 1,000 IU
50CholesterolT Reduced 4 mg RCT, 400 IU + Ca 41

   * Proof # Vitamin D Proof: Random controlled Trials  Updated May 2014

PDF is attached at the bottom of this page June 2014 1pg Legal English

Following curve indicates that probably want to take 50,000 IU of vitamin D at least every two weeks.

50000 IU monthly is not a lot

Notes on 50,000

  • Lowest-cost form of vitamin D3 (about 2 cents per 5,000 IU)
  • The half life of vitamin D3 is measured in weeks - so taking 50,000 every few weeks is OK (half life of vitamin D2 is measured in days)
  • This is the size of vitamin D that doctors have been used to prescribing for many decades - generally as a loading dose every week or two.
  • Now doctors can prescribe Vitamin D3 instead of D2
  • This has has very low toxicity - even if accidentally taken daily, the toxicity does not occur until it has been taken daily for 3 months
  • Can be even used by those who cannot swallow pills (the powder in the capsule is tasteless and can be taken directly or in food or beverage

Cofactors appear to be needed if dosing more frequently than every 20 days for months

Easy to remember to take vitamin D - just mark your calendar

Bio-Tech Pharmacal started selling their 50,000 IU vitamin D capsules in the US in 2000.

As of March 2012, their 50,000 IU size was widely available in the US and on the internet
They also sell 5,000 IU capsules. The 5,000 IU and 50,000 IU sizes are available both over the counter and as a prescription. These are NOT new products.
It is available on the internet in via many suppliers, such as Amazon $20 for 100 capsules.
Bio-Tech has supplied products to over 40 institutions for use in clinical research, usually at no cost
The PDF attached at the bottom of this page details their US and international distributors as of Sept 2012.
The wholesale cost of 50,000 IU of D3 is about 15 cents. (D2. which doctors previously prescribed, is much more expensive and not nearly as good
Their capsules are made from beef (non-pork: Kosher/Halal approved)
Vegi capsules (without beef) are available, but are more expensive

As of Feb 2013 Bio-tech is 1 of 2 suppliers for 50,000 IU on Amazon (there is another company which has 25,000 IU capsules
As of Oct 2012 there were 41 public clinical trials using/had used Bio-Tech supplements
   28 of the clinical trials used 50,000 IU of vitamin D

    Summary is attached as a PDF file at the bottom of this page

See also VitaminDWiki

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