Table of contents
- Comparison of nutritional supplements for glycemic control in type 2 diabetes: A systematic review and network meta-analysis of randomized trials
- VitaminDWiki -
38 Diabetes Meta-analyses
Comparison of nutritional supplements for glycemic control in type 2 diabetes: A systematic review and network meta-analysis of randomized trials
Diabetes Research and Clinical Practice. Vol 191, Sept 2022, https://doi.org/10.1016/j.diabres.2022.110037 PDF is behind $28 paywal
AsmaKazem ia, SungRyul Shim b NavidJamalic ZahraHassanzadeh-RostamidSepidehSoltanieNajmehSasanidMohammad AliMohsenpourfgDonyaFiroozifg ReyhaneBasiratd RaziehH osseinihCain C.T.ClarkiSiavashBabajafaridMozhganSoltanmohammadihDirect and indirect evidence were combined in this systematic-review and network meta-analysis (NMA) to assess and compare the effect of nutritional supplements on glycemic control, and rank the supplements accordingly.
Methods
PubMed, Scopus, and Web of Science were searched up to April 2021. We included randomized controlled trials that investigated the effect of vitamins D, C, and E, magnesium, zinc, calcium, selenium, and omega-3 on at least one glycemic marker, including glycated hemoglobin (HbA1c), fasting blood sugar (FBS), homeostasis model assessment-estimated insulin resistance (HOMA-IR), HOMA-B, and insulin, in adults with type 2 diabetes. To estimate effectiveness of supplements, a random-effects NMA in the Bayesian framework was applied. To assess risk of bias, Cochrane Collaboration Tool was used.\Results
Analysis of 178 studies indicated that zinc, vitamin D, omega-3, vitamin C, and vitamin E were effective in reducing HbA1c with low certainty. For reduction of FBS, zinc, vitamin D, and vitamin C, and for HOMA-IR, vitamin D were effective with low certainty. None of the supplements were effective in the reduction of insulin and HOMA-B with low certainty.
After excluding poor-quality studies, only vitamin D was significantly effective in reducing all of the markers.
Consistently, when the analysis was restricted to studies with a duration of ≥12-weeks, vitamin D reduced HbA1c, FBS, and HOMA-IR.Conclusions
Vitamin D supplementation was more effective compared to other supplements in improving HbA1c, FBS, and HOMA-IR, albeit with low certainty of evidence. This result was confirmed by low-risk of bias studies.Registration: CRD42021240691.
VitaminDWiki -
38 Diabetes Meta-analyses This list is automatically updated
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- Glycemic control of type 2 diabetes – only Vitamin D had high quality studies – meta-analysis Sept 2022
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Insulin Resistance is associated with low Vitamin D (both diabetic and non-diabetic) – meta-analysis May 2021
- Diabetic Neuropathy 2.8X higher risk if low vitamin D – meta-analysis May 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
- Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis April 2019
- Vitamin D helps Diabetic Nephropathy kidneys – meta-analysis April 2019
- Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019
- Diabetic Foot Ulcer 3.2 X or 3.6 X more likely if low vitamin D – several meta-analyses
- Prediabetes treated by Vitamin D (34 ng, 3500 IU per day) – meta-analysis May 2018
- Diabetics helped by vitamin D in 5 ways – meta-analysis June 2018
- Diabetes treated and prevented by more than 2,000 IU of vitamin D (need more and gut-friendly) - meta-analyses 2018
- Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018
- Diabetic inflammation reduced by Vitamin D – meta-analysis Feb 2018
- Type 1 Diabetes (T1DM) 1.6 X more likely if low vitamin D – meta-analysis Jan 2018
- Hyperglycemia associated with low vitamin D – type II diabetics and healthy people – meta-analysis Jan 2018
- Diabetes helped by daily 4,000 IU of Vitamin D – meta-analysis Sept 2017
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Diabetic Retinopathy twice as likely if a T2 Diabetic has low level of vitamin D – meta-analysis March 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
- Diabetic Retinopathy 27 percent more likely if low vitamin D – meta-analysis May 2016
- Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015
- Diabetes not prevented by Vitamin D (when you ignore how much vitamin D was taken) – Sept 2015
- Diabetics are 2.7 X more likely to get peripheral neuropathy if low vitamin D – meta-analysis Dec 2014
- Diabetes not prevented or treated if give only modest amount of vitamin D or for short period of time – meta-analysis July 2014
- Type 2 diabetes 1.5X more likely if low vs high vitamin D – meta-analysis Feb 2013
- 4 percent less type 2 diabetes for every 4 ng more vitamin D – meta-analysis May 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012
- Diabetes down 13 percent if more than 500 IU of vitamin D – meta-analysis July 2011
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