Glaucoma 3.1 X more likely if a poor Vitamin D Receptor – Sept 2020

Vitamin D and its receptor polymorphisms are associated with glaucoma

J Fr Ophtalmol . 2020 Sep 28;S0181-5512(20)30400-9. doi: 10.1016/j.jfo.2020.02.016.
Z S Ulhaq 1


Note: Problems with the Vitamin D Receptor are not notice by vitamin D blood tests

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Items in both categories Vision and Vitamin D Receptor are listed here:

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

7+ VitaminDWiki pages with GLAUCOMA in title

This list is automatically updated

Items found: 7

Purpose: To clarify the association between serum vitamin D levels and its receptor polymorphisms with glaucoma risk.

Methods: A meta-analysis was performed from available studies investigating serum vitamin D levels and vitamin D receptor (VDR) polymorphisms in glaucoma patients and controls.

Results: Twelve studies in total, including 130,676 and 476 subjects, were analysed for the association between serum vitamin D levels and VDR polymorphisms with glaucoma, respectively. Collectively, it was found that glaucoma patients have lower levels of vitamin D compared to controls (SMD=-1.16, 95% CI=-1.56 0.76, P<0.00001). In parallel, the pooled results showed a significant association between glaucoma and allelic (b vs. B, OR=1.84, 95% CI=1.37-2.46, P=0.00001) and recessive (bb vs. Bb+BB, OR = 3.16, 95% CI=1.30-7.66, P=0.001) models of VDR BsmI (rs1544410) polymorphism, but not with VDR TaqI (rs731236) or FokI (rs2228570) polymorphisms.

Conclusion: This meta-analysis suggests that patients with glaucoma may have vitamin D deficiency. In addition, the vitamin D signalling cascade may be a contributing factor in developing glaucoma, which is supported by the evidence that b allele carriers of VDR BsmI exhibited an increase in the risk of glaucoma. Thus, dietary supplementation of vitamin D may become an important approach as an additional treatment for glaucoma.

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