Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome
Neuropsychiatric Disease and Treatment Volume 2019:15 Pages 1421—1426, DOI https://doi.org/10.2147/NDT.S198434
- Overview Fibromyalgia or Chronic Fatigue and vitamin D
"Large doses of vitamin D reduced CFS/Fibromyalgia in > 10 studies"
"Many books and online forums recommend vitamin D for CFS/Fibromyalgia" - Fibromyalgia associated with lower Vitamin D – meta-analysis Oct 2017
- Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019
Pain - chronic category has the following
See also
- Overview Pain and Vitamin D
- Percentage of people with pain increased 25 percent in 18 years – Jan 2019
- Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
- Overview Fibromyalgia or Chronic Fatigue and vitamin D
- Overview Rheumatoid Arthritis and vitamin D
- Shingles and vitamin D
- Shin splints decrease with vitamin D
- Migraine and Vitamin D
- Headache category
79 items - "musculoskeletal pain" 490 items as of Aug 2023
- "chronic fatigue" 185 items as of Jan 2017
- Category Back Pain
42 items - 7 pain studies in VitaminDWiki with KNEE in the title as of Aug 2023 (see below)
- Opioid OR Opiate OR Morphine in the title 10 pages as of June 2021
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Omar A Amin,1 Saleh M Abouzeid,2 Siham A Ali,3 Bashir A Amin,4 Khaled A Alswat5
1Department of Orthopedic, Al Noor Specialist Hospital, Makkah, Saudi Arabia; 2Department of Rheumatology, Al Azhar University, Cairo, Egypt; 3Department of Neurology, Banha University, Banha, Egypt; 4Department of Medicine, Taif University, School of Medicine, Taif, Saudi Arabia; 5Department of Medicine and Endocrinology, Taif University School of Medicine, Taif, Saudi ArabiaObjective: Fibromyalgia syndrome (FMS) is a chronic disorder associated with severe pain. According to the National Fibromyalgia Association, the prevalence of FMS is between 3% and 6% in the general population, with about 90% of the patients being women. The primary goal of this study was to evaluate the relationship between vitamin D and serotonin levels and FMS severity.
Methods: Forty participants with fibromyalgia (mean age: 37.8±9.5 years) were included and had their medical history taken, a physical examination, and laboratory testing in the Rheumatology Department at Al-Ameen Hospital in Taif, Saudi Arabia. The revised Fibromyalgia Impact Questionnaire (FIQR) was used to determine the FMS severity.
Results: The results showed that 42.5% of the patients were considered to have mild/moderate fibromyalgia, with the remainder having severe/extreme fibromyalgia. The latter were more likely to have lower serotonin levels. The results showed a significant dose-dependent negative relationship between the serotonin levels and FIQR scores (P=0.002). However, no significant correlations were found between the vitamin D levels and FIQR scores (P=0.112).
Conclusion: The findings of this study show that the improved health of FMS patients is associated with normal serotonin levels.
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