Large Meta-Analysis in the CHARGE Consortium Provides Evidence For an Association of Serum Vitamin D With Pulmonary Function
Biorxiv Preprint, doi: https://doi.org/10.1101/144717
For each 1 nmol more vitamin D FEV1
- 1.1 milliliter more if European Ancestry
- 1.8 milliliter more if Afrian Ancestry
For each 1 nmol more Vitamin D the Total Capacity for European Ancestry
- .1.7 millilitter if current or former smoker
- 0.8 millilitter if never-smoker
- More lung capacity (bronchial asthma, FEV1) associated with higher vitamin D – July 2013
- Worse breathing with COPD is related to lower Vitamin D – June 2018
Breathing category starts with the following
- Smoking reduces vitamin D - many studies
- Breathing by ever-smokers improved by monthly Vitamin D – RCT 2017
- Smoking associated with 9 ng less vitamin D age 40-50 – Nov 2014
The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for the association of serum 25-hydroxyvitamin D [25(OH)D] and pulmonary function. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n=22,838) and five African ancestry (AA) cohorts (n=4,290) in the CHARGE Consortium. Data were analyzed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested.
Results were combined using fixed-effects meta-analysis.
Mean (SD) serum 25(OH)D was
- 68 (29) nmol/L for EAs and
- 49 (21) nmol/L for Aas.
For each 1 nmol/L higher 25(OH)D, forced expiratory volume in the first second (FEV1) was higher by
- 1.1 mL in EAs (95% CI: 0.9,1.3; P=2.5×10-21) and
(1.8 mL (95% CI: 1.1,2.5; P=1.6×10-7) in AAs (Prace difference=0.06), and
forced vital capacity (FVC) was higher by
- 1.3 mL in EAs (95% CI: 1.0,1.6; P=1.1×10-20) and
- 1.5 mL (95% CI: 0.8,2.3; P=1.2×10-4) in AAs (Prace difference=0.56).
Among EAs, the 25(OH)D-FVC association was stronger in smokers: per 1nmol/L higher 25(OH)D,
- FVC was higher by 1.7 mL (95% CI: 1.1,2.3) for current smokers and
- 1.7 mL (95% CI: 1.2,2.1) for former smokers, compared to
- 0.8 mL (95% CI: 0.4,1.2) for never smokers.
In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EAs, a stronger association was observed for smokers compared to never smokers, which supports the importance of vitamin D in vulnerable populations.