Children who wheezed were 2.7X more likely to have little vitamin D – April 2014


Subnormal levels of vitamin D are associated with acute wheeze in young children

Acta Paediatrica, DOI: 10.1111/apa.12666
Katarina Stenberg Hammar 1,2,*, Gunilla Hedlin 1,2, Jon R. Konradsen1,2, Björn Nordlund1,2, Inger Kull3,4, Christian G. Giske5, Christophe Pedroletti6, Cilla Söderhäll7 andErik Melén3,8
1Astrid Lindgren Children′s Hospital, Karolinska University Hospital, Stockholm, Sweden
2Department of Women′s and Children′s Health, Karolinska Institutet, Stockholm, Sweden
3Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
4Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
5Clinical Microbiology, MTC, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
6Department of Women′s and Childrens′s Health, Uppsala University, Uppsala, Sweden
7Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
8Sachs′Children′s Hospital, Södersjukhuset, All belong to The Centre for Allergy Research at Karolinska Institutet, Stockholm, Sweden
* Address correspondence to: Katarina Stenberg Hammar, Allergy Research Unit, Astrid Lindgren Children′s Hospital, Karolinska University Hospital, Solna, SE-171 76 Stockholm, Sweden. katarina.stenberg-hammar@karolinska.se]Tel: + 46 70 780 34 38

Aim
This study evaluated risk factors for acute wheeze in preschool children and investigated if subnormal levels of vitamin D were associated with increased risk for acute wheeze, atopy or viral/bacterial respiratory infections.

Methods
We recruited 130 children with acute wheeze, aged six months to four years, from paediatric emergency departments in Stockholm, Sweden, and 101 age-matched controls with no history of wheeze or sensitisation to airborne allergens. Parents answered standardised questionnaires and blood samples were analysed for specific IgE to airborne and food allergens and levels of 25 hydroxyvitamin D (25(OH)D). Nasopharyngeal virus samples were collected during the emergency department visit in the group of children with wheeze and a subset were also tested for bacteria.

Results
Vitamin D insufficiency (25(OH)D <75nmol/L (30 ng/mL) was associated with an odds ratio of 2.7 (95% confidence interval 1.1-6.2) for acute wheeze. However, no association was found between vitamin D insufficiency and atopy, presence of virus or bacteria or recurrent infections. Children older than 24 months were particularly at risk of subnormal vitamin D levels, irrespective of wheezing history.

Conclusion
Our findings support the hypothesis that subnormal levels of vitamin D are associated with acute wheeze in young children.


Published offers low cost access to patients and care providers


15+ VitaminDWiki pages have WHEEZING in the title

This list is automatically updated

Items found: 15
Title Modified
Vitamin D levels are low during Recurrent Wheezing - Feb 2024 24 Feb, 2024
Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023 21 Dec, 2023
Recurrent Wheezing in children is associated with low Vitamin D – several studies 04 Sep, 2022
Wheezing and asthmatic children have weaker Vitamin D responses - May 2022 19 May, 2022
Vitamin D reduces RTI, Omega-3 reduces wheezing or asthma – March 2022 11 Apr, 2022
Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019 04 Apr, 2020
Gene which predicts wheezing is associated with low vitamin D – Oct 2019 18 Oct, 2019
Black infant recurrent wheezing rate dropped from 42 percent to 31 percent with just 400 IU of vitamin D – RCT Dec 2018 06 Dec, 2018
Recurrent wheeze 2X more likely if endotoxin (on some bacteria) and low vitamin D – May 2016 15 Dec, 2017
Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015 10 May, 2016
2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015 09 Sep, 2015
Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015 25 Aug, 2015
Children who wheezed were 2.7X more likely to have little vitamin D – April 2014 18 Apr, 2015
Vitamin D and wheeze – especially in seniors – Aug 2011 26 Apr, 2014
Single dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013 30 Jun, 2013

4923 visitors, last modified 24 Feb, 2024,
Printer Friendly Follow this page for updates