Chance of dying within 1 month of entering hospital is 45 percent higher if low vitamin D – July 2013

Pre-hospital Vitamin D Concentration, Mortality, and Bloodstream Infection in a Hospitalized Patient Population

The American Journal of Medicine; Volume 126, Issue 7, July 2013, Pages 640.e19–640.e27
Nancy Lange, MD, MPHa,
Augusto A. Litonjua, MD, MPHb,
Fiona K. Gibbons, MDc,
Edward Giovannucci, MD, ScDd,
Kenneth B. Christopher, MDe, kbchristopher@partners.org
a Pulmonary Division, Brigham and Women's Hospital, Boston, Mass
b Channing Laboratory and Pulmonary and Critical Care Division, Brigham and Women's Hospital, Boston, Mass
c Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Mass
d Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Mass
e Renal Division, Brigham and Women's Hospital, Boston, Mass

Objective: The study objective was to examine the association between pre-hospital serum vitamin D concentration and mortality after hospitalization.

Methods: We performed a retrospective cohort study in 2 tertiary hospitals in Boston, Mass, on 23,603 patients aged ≥18 years in whom 25(OH)D was measured before hospitalization between 1993 and 2010. The main outcome measures were all-cause mortality by day 30 post-hospital admission, in-hospital mortality, and community-acquired bloodstream infection.

Results: Compared with patients with pre-hospital 25(OH)D ≥30 ng/mL, patients with pre-hospital 25(OH)D ≤15 ng/mL or 15 to 30 ng/mL have higher odds of mortality 30 days after hospital admission.

After adjustment for age, gender, race, Deyo-Charlson index, season, type (surgical vs medical), creatinine, blood urea nitrogen, hematocrit, and time between 25(OH)D draw and hospital admission, the adjusted odds ratio (OR) of 30-day mortality in patients with 25(OH)D ≤15 ng/mL is 1.45 (95% confidence interval [CI], 1.21-1.74; P < .0001) and the adjusted OR of 30-day mortality in patients with 25(OH)D 15 to 30 ng/mL is 1.30 (95% CI, 1.10-1.54; P = .003) both compared with patients with pre-hospital 25(OH)D ≥30 ng/mL. In a subgroup analysis of patients who had blood cultures drawn (n = 5628), pre-hospital serum 25(OH)D ≤15 ng/mL was associated with increased odds of community-acquired bloodstream infection (adjusted OR, 1.29; 95% CI, 1.06-1.57; P = .01) relative to patients with 25(OH)D ≥30 ng/mL.

Conclusions: Analysis of 23,603 hospitalized patients identified both 25(OH)D ≤15 ng/mL and 25(OH)D 15 to 30 ng/mL before hospital admission as associated with the odds of all-cause patient mortality at 30 days after hospitalization. In addition, pre-hospital serum 25(OH)D ≤15 ng/mL is significantly associated with the odds of community-acquired bloodstream infection.

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Dr. Ray Matthews is a US surgeon who prefers that his elective surgery patients have 50-70 ng/ml of vitamin D
Restore your vitamin D levels before entering the hospital! Restoration can be done very quickly,

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