COVID death 1.5 X less likely if high vitamin D, emergency D (50K to 100K) is great – meta-analysis March 2023

Vitamin D on COVID-19 Patients During The Pandemic, 2022, A systematic Review and MetaAnalysis

Current Research in Nutrition and Food Science Journal - March 2023
Moamen Mostafa Asia1 Ï , Asmaa Ahmed Nawar 1. , Esraa Elsayed2 , Ramadan, Abdelmoez Farahat5 , Ayah Abdulgadir6 , Mostafa Abdullah Alsharabasy1 , Israa Mohamed Elshahawy7 and Samar A. Amer2,3,4

Numerous connections between the level of vitamin D (Vit-D) and the novel coronavirus disease -19 (COVID-19) have surfaced during the pandemic. So, we conducted this systematic review and meta-analysis to explore the effect of Vit-D deficiency and its supplementation on the clinical outcomes of COVID-19 patients. We looked for relevant articles in Cochrane Library, Scopus, Web Science, PubMed, and EBSCO up until the end of 2022. The Open Meta Analyst software was used to analyze the extracted data. We classified them into two main categories based on their objectives. First, the studies that evaluated the effects of Vit-D deficiency in patients, and lastly, the studies that evaluated Vit-D as a supplement, both on mortality rate, hospitalization duration, ICU admission rate, and mechanical ventilation rate. A total of 8001 COVID-19 patients from 42 studies were included. A high serum Vit-D concentration compared to those with lower levels was associated with a significantly lower mortality rate (RR = 1.5, 95% CI = 1.11: 2.02, p = 0.01). According to the estimated effect of 18 studies, those who took Vit-D supplements had a significantly lower mortality rate, hospitalization duration, ICU admission rate, and mechanical ventilation rate than those who did not. The group receiving Vit-D doses between 50 000 to 100 000 IU had a significantly better clinical outcome compared to lower and higher doses. COVID-19 patients with normal Vit-D levels had significantly lower death rates than those with hypovitaminosis. Vit-D supplements in COVID-19 significantly improved clinical outcomes. Vit-D supplementation between 50 000 to 100 000 IU, in patients with COVID-19 significantly


This systematic review and meta-analysis came to the conclusion that compared to COVID-19 cases with hypovitaminosis D, cases with normal vitamin D levels significantly showed lower mortality rates. Vitamin D supplementation greatly improved death rates, length of hospital stays, ICU admission rates, and the need for mechanical ventilation, especially when this vitamin was given to patients after their diagnosis of COVID-19. Vitamin D supplementation between 50 000 to 100 000 IU, showed among COVID-19 patients significantly outperformed other doses in terms of mortality
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42 Meta-analyses of Virus

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