Correlation between vitamin D serum levels and passive smoking exposure in children with asthma
Allergy and Asthma Proceedings, Vol 39, # 3, May/June 2018, pp. e8-e14(7),
DOI: https://doi.org/10.2500/aap.2018.39.4124
| 20.5 ng | parents not smoke |
| 14.5 ng | both parents smoke |
- Smoking reduces vitamin D - many studies
- Child exposed to smoke is 1.5 X more likely to have low vitamin D – Oct 2018
- Little second-hand smoke problem in children if mother had added Vitamin D while pregnant - RCT Feb 2023
- Vitamin D and allergy, asthma, atopic dermatitis, food allergy, autoimmune, etc – slides May 2017 by Dr. Boner (who is an author of the study on this page)
See also web
- Download the 2006 Surgeon General's Report on 2nd hand smoke
- Maternal Second-Hand Smoke Exposure in Pregnancy Is Associated With Childhood Asthma Development March 2014
"Children whose mothers smoked or were exposed to home second-hand smoke during pregnancy were more likely to develop asthma (adjusted hazard ratio [HR] 1.3" - Passive smoking residue stunts babies’ growth and harms immune system Feb 2017
- The Dangers of Third Hand Smoke - from furniture, clothing, walls, carpets, etc.
- The effect of cigarette smoke exposure on vitamin D level and biochemical parameters of mothers and neonates May 2013 - free PDF
Chinellato, Iolanda1; Piazza, Michele2; Sandri, Marco3; Paiola, Giulia2; Tezza, Giovanna2; Boner, Attilio L.2
1: From the Department of Paediatrics, P.O.C. SS. Annunziata Hospital, Taranto, Italy 2: Section of Paediatrics, Department of Surgery, Dentistry, Gynaecology and Paediatrics, University of Verona, Verona, Italy 3: Data Methods and System Statistical Laboratory, University of Brescia, Brescia, Italy
To establish the relationship between vitamin D serum levels, pulmonary function, asthma control, and passive smoking exposure in children with asthma.
Methods: We studied the relationship between 25-hydroxy cholecalciferol (25OHD) concentrations and baseline spirometry and levels of asthma control, and the effect of parental tobacco smoke exposure in 152 white children (84 boys [55.3%]) with a mean age ± standard deviation of 9.9 ± 2.0 years (range 5‐15 years) in a cross-sectional study carried out during the winter and early spring.
Results: Only 9.9% of our children had a sufficient serum 25(OH)D level (at least 30‐40 ng/mL). A significant positive correlation was found between the force vital capacity % predicted, forced expiratory volume in the first second of expiration % predicted, and serum 25(OH)D level (r = 0.36, p < 0.001 for both). The subjects with controlled asthma had higher serum levels of 25(OH)D than children with partially controlled or noncontrolled asthma, both according to Global Initiative for Asthma parameters and the Test for the control of asthma in childhood (p = 0.011). Children with both nonsmoking parents presented significantly higher serum levels of 25(OH)D than children with both smoking parents (median, 20.5 ng/mL [interquartile range {IQR}, 16.6‐24.0 ng/mL] versus median, 14.5 ng/mL [IQR, 11.1‐19.1 ng/mL], respectively; p < 0.001), with intermediate values for children exposed to single maternal (median, 20.3 ng/mL [IQR, 13.0‐23.2 ng/mL]) or to paternal smoking (median, 17.8 ng/mL [IQR, 14.7‐22.1 ng/mL]).
Conclusion: Our results indicated that hypovitaminosis D was frequent in children with asthma who lived in a Mediterranean country. In these children, lower levels of vitamin D were associated with reduced asthma control and passive smoking exposure.