Bone diseases related to many Vitamin D diseases – June 2016

Crucial Role of Vitamin D in the Musculoskeletal System

www.mdpi.com/journal/nutrients May 2016; Published: 1 June 2016
Elke Wintermeyer, Christoph Ihle, Sabrina Ehnert, Ulrich Stockle, Gunnar Ochs, Peter de Zwart, Ingo Flesch, Christian Bahrs and Andreas K. Nussler andreas.nuessler@gmail.com

VitaminDWiki

Overview Osteoporosis and vitamin D contains the following summary

FACT: Bones need Calcium (this has been known for a very long time)
FACT: Vitamin D improves Calcium bioavailability (3X ?)
FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
FACT: Vitamin D supplements are very low cost
FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
FACT: Co-factors help build bones.
FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
It appears that to TREAT Osteoporosis:
Calcium OR vitamin D is ok
Calcium + vitamin D is good
Calcium + vitamin D + other co-factors is great
Low-cost Vitamin D Receptor activators sometimes may be helpful
CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
Category Osteoporosis has 227 items
Category Bone Health has 319 items

Note: Osteoporosis causes bones to become fragile and prone to fracture
Osteoarthritis is a disease where damage occurs to the joints at the end of the bones
Osteoporosis category includes the following

227 items in category - see also Overview Osteoporosis and vitamin D
Overview Fractures and vitamin D
Bone - Health 319 items
VitaminDWiki pages with BONE MINERAL DENSITY or BMD in title 29+ pages
Search VitaminDWiki for OSTEOPENIA 1740 items as of July 2020
13 articles are in both Osteroporosis and Vitamin D Receptor categories
10 articles are in both Osteroporosis and Meta-analysis categories
20X increase in vitamin D sold and 36 percent decrease in osteoporosis business in Australia – Nov 2013

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Studies showing relationship of diseases to both Osteopenia (Bone pain) and Osteoporosis

Vitamin D is well known to exert multiple functions in bone biology, autoimmune diseases, cell growth, inflammation or neuromuscular and other immune functions. It is a fat-soluble vitamin present in many foods. It can be endogenously produced by ultraviolet rays from sunlight when the skin is exposed to initiate vitamin D synthesis. However, since vitamin D is biologically inert when obtained from sun exposure or diet, it must first be activated in human beings before functioning. The kidney and the liver play here a crucial role by hydroxylation of vitamin D to 25-hydroxyvitamin D in the liver and to 1,25-dihydroxyvitamin D in the kidney. In the past decades, it has been proven that vitamin D deficiency is involved in many diseases. Due to vitamin D's central role in the musculoskeletal system and consequently the strong negative impact on bone health in cases of vitamin D deficiency, our aim was to underline its importance in bone physiology by summarizing recent findings on the correlation of vitamin D status and rickets, osteomalacia, osteopenia, primary and secondary osteoporosis as well as sarcopenia and musculoskeletal pain. While these diseases all positively correlate with a vitamin D deficiency, there is a great controversy regarding the appropriate vitamin D supplementation as both positive and negative effects on bone mineral density, musculoskeletal pain and incidence of falls are reported.